Evidence map›Paper›PMID 42750948›Full record

ReviewGenes & diseases2027

Functions of exosome-derived noncoding RNA-encoded polypeptides/proteins in human diseases.

Xinyuan Feng, Meihuan Chen, Dahang Ye, Ying Zhu, Liangpu Xu, Hailong Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinyuan FengMedical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Provincial Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian 350001, China.
Meihuan ChenMedical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Provincial Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian 350001, China.
Dahang YeMedical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Provincial Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian 350001, China.
Ying ZhuMedical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Provincial Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian 350001, China.
Liangpu XuMedical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Provincial Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian 350001, China.
Hailong HuangMedical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Provincial Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian 350001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nanoscale vesicles that are ubiquitously present in biological fluids and exhibit remarkable stability, carrying a diverse array of biologically active molecules, including various RNAs, DNAs, and proteins. Exosomes are crucial mediators of intercellular signaling and exert extensive regulatory effects on nearly all physiological and pathological processes in the body. Traditionally, noncoding RNAs (ncRNAs) were deemed incapable of encoding proteins, but recent studies have demonstrated that noncoding RNAs harbor a substantial number of open reading frames, which possess the potential to encode peptides/proteins that are implicated in the pathogenesis and progression of various diseases. This review aims to comprehensively summarize the roles and mechanisms of exosome-derived ncRNA-encoded polypeptides/proteins (EDNEPs) in common diseases across nine major physiological systems, including the hematological, motor, digestive, respiratory, urinary, endocrine and reproductive, circulatory, immune, and nervous systems. Additionally, this review seeks to provide references for the clinical application of EDNEPs as diagnostic and prognostic biomarkers, promising therapeutic agents, and potential therapeutic targets.

Indexed as

BiomarkersEDNEPsExosomesncRNAsTherapeutic target

Identifiers

PMID42750948
PMCPMC13579305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.