Evidence map›Paper›PMID 42750874›Full record

ArticleFood chemistry: X2026

Decoding the bioactive peptides and metabolic fingerprints of whey derived from dairy fan processing by-products.

Wenli Tao, Zhenzhu Li, Wei Du, Yue Wang, Ruonan Dai, Yanan Shi, Hong Li, Qiuling Tan, Aixiang Huang, Guangqiang Wei and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenli TaoCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Zhenzhu LiCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Wei DuCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Yue WangCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Ruonan DaiCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Yanan ShiCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Hong LiCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Qiuling TanCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Aixiang HuangCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Guangqiang WeiCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.
Yufang LiCollege of Food Science & Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whey contains abundant nutrients and bioactive compounds with health benefits, but functional peptides and metabolites in Dairy fan whey (Whey generated during dairy fan processing, DFW) remain underexplored. Therefore, this study identifies DFW nutritional profile and bioactivity via peptidomics, nontargeted metabolomics, and in vitro experiments. The results showed that a variety of bioactive peptides were identified, including antioxidant peptides and angiotensin-converting enzyme (ACE) inhibitory peptides. Four antioxidant peptides interact with Keap1 via hydrogen bonds and salt bridges, thereby exerting antioxidant effects and regulating the Keap1-Nrf2/ARE pathway. In vitro assays confirmed that DFW scavenged DPPH, ABTS, and hydroxyl radicals, demonstrating strong antioxidant activity. Additionally, 919 metabolites were identified in DFW and conventional whey (W), including 15 characteristic compounds such as 4-aminobutyric acid, histamine, and pyridoxine. These characteristic metabolites exhibit antioxidant, anti-inflammatory, and immunoregulatory activities. Compared with W, DFW contains more characteristic nutrients. Overall, this study provides a theoretical basis for the high-value utilization of DFW.

Indexed as

Antioxidant activityBioactive peptidesDairy fan processingMetabolomicsWhey

Identifiers

PMID42750874
PMCPMC13578985

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.