ArticleJournal of clinical & translational endocrinology2026
Post-exercise hypoglycaemia in adults with cystic fibrosis compared to healthy control adults.
Article in Journal of clinical & translational endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: People with cystic fibrosis-related diabetes (CFRD) are at risk of hypoglycaemia related to insulin therapy; and hypoglycaemia is also prevalent in those without CFRD. Although people with other forms of diabetes mellitus are at risk of hypoglycaemia within 48 h after exercise, this has not been objectively measured in people with CF. This study investigated the prevalence of post-exercise hypoglycaemia in adults with CF (pre- and post-commencement of elexacaftor/tezacaftor/ivacaftor (ETI)), compared to healthy controls. Methods: Participants completed a 20-min supervised, moderate-intensity cycling session and wore a continuous flash glucose sensor. The prevalence of hypoglycaemia was defined as the number of participants and percentage of time glucose levels were < 3.9 mmol/L and < 3.0 mmol/L within the 48 h after exercise. Results: 15 adults with CF pre-ETI (abnormal glucose tolerance (impaired glucose tolerance, Conclusions: The absence of any increase in significant hypoglycaemia in the post-exercise period should be reassuring for people with CF who have abnormal glucose tolerance, whether prescribed ETI or not, and their clinicians.
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