Evidence map›Paper›PMID 42750787›Full record

ArticleiScience2026

Oxytocin receptor signaling contributes to the mitochondrial integrity and maintain gastric mucosal homeostasis in male mice.

Yuko Maejima, Shoko Yokota, Megumi Yamachi, Takayuki Yabe, Eugenio Vecchi, Miho Aoki, Saki Shimoyama, Tomoyuki Ono, Daisuke Nakajima, Yoko Teruuchi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuko MaejimaDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Shoko YokotaDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Megumi YamachiDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Takayuki YabeDepartment of Anatomy and Histology, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Eugenio VecchiDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Miho AokiAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima-shi, Fukushima 960-1295, Japan.
Saki ShimoyamaAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima-shi, Fukushima 960-1295, Japan.
Tomoyuki OnoDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Daisuke NakajimaDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Yoko TeruuchiMedical Division, Nittoboseki Co., Ltd., Koriyama-shi, Fukushima 963-8061, Japan.
Masao FukushimaResearch and Development Headquarters, Nittoboseki Co., Ltd., Koriyama-shi, Fukushima 963-8061, Japan.
Shizu HidemaDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Katsuhiko NishimoriDepartments of Obesity and Inflammation Research, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Hitoshi KuboDepartment of Radiological Sciences, School of Health Sciences, Fukushima Medical University, Fukushima-shi, Fukushima 960-8516, Japan.
Satoshi WaguriDepartment of Anatomy and Histology, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.
Songji ZhaoAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima-shi, Fukushima 960-1295, Japan.
Heidi de WetDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Kenju ShimomuraDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima-shi, Fukushima 960-1295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of oxytocin receptor (OXTR) signaling in the stomach remains poorly understood. This study investigates the physiological and pathophysiological role of OXTR signaling in parietal cells. Using wild type (wt), OXT null and OXTR null mice fed either a standard diet (SD) or a high fat diet (HFD), we examined the effects of OXT and OXTR signaling on gastric mucosa histology and function. SD-fed mice lacking active OXTR/OXT showed mucosal hyperplasia, which was reversed by subcutaneous OXT administration in OXT null mice. HFD-fed wt mice developed typical gastric mucosal hyperplasia, parietal cell atrophy with mitochondrial damage, and impaired

Indexed as

18F-fluorodeoxyglucoseAMPKCOX IVhigh fat dietmitochondriaoxytocin receptorsparietal cells

Identifiers

PMID42750787
PMCPMC13577885

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.