ArticleRadiology case reports2026
"Ears of the lynx" sign on MRI: A radiologic clue to hereditary spastic paraplegia.
Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hereditary spastic paraplegia (HSP), also known as Strümpell-Lorrain disease, comprises a heterogeneous group of inherited neurodegenerative disorders characterized by progressive lower-limb spasticity resulting from corticospinal tract degeneration. Clinically, HSP is divided into a pure form, limited to pyramidal tract signs, and a complicated form associated with additional neurological manifestations. We report a familial case involving 2 male siblings born to consanguineous parents who presented with complicated HSP. Brain magnetic resonance imaging demonstrated thinning of the corpus callosum and a characteristic T2/FLAIR cone-shaped hyperintensity at the anterior horns of the lateral ventricles, known as the "ears of the lynx" sign. This radiologic feature is strongly associated with SPG11 and SPG15, 2 common genetic subtypes of complicated HSP. In regions where genetic testing is limited by availability or cost, recognition of this imaging sign may provide an important diagnostic clue and facilitate early identification of hereditary spastic paraplegia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.