Evidence map›Paper›PMID 42750434›Full record

ArticleEndocrine, metabolic & immune disorders drug targets2026

Impact of Clinical Factors on Bone Microarchitecture in Patients with Turner Syndrome.

Isabella Nardone, Sium Wolde Sellasie, Simona Zaccaria, Marina Passeri, Luca Giudice, Lorenza Mattia, Cristina Giusto, Rossella Antonelli, Stefania Falcone, Laura Giurato and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Isabella NardoneDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID 0000-0002-7641-7625
Sium Wolde SellasieDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.
Simona ZaccariaDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.
Marina PasseriDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.
Luca GiudiceDivision of Endocrinology and Diabetes, Fondazione Policlinico Tor Vergata, Rome, Italy.
Lorenza MattiaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Cristina GiustoDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.
Rossella AntonelliDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.
Stefania FalconeDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.
Laura GiuratoDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.
Luigi UccioliDivision of Endocrinology and Diabetes, Department of Surgical Sciences, CTO Andrea Alesini Hospital, University of Rome Tor Vergata, 00133, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients affected by Turner syndrome (TS) suffer from bone fragility and a high risk of fractures. The health of bone microarchitecture has proven to be a very important element in reducing the risk of fractures. The present study aimed to describe bone characteristics of patients with TS and highlight clinical factors that can influence bone microarchitecture, evaluated by the trabecular bone score (TBS).

methodsThis single-centre retrospective study included 41 patients with TS who attended the Endocrinology Day Hospital of the CTO Hospital of Rome between 2016 and 2024. Anthropometric, clinical, and densitometric data were collected and analysed using unadjusted univariate models, age- and body mass index-adjusted models, and multivariate analysis to investigate their effects on TBS.

resultsThere was a positive association between TBS and duration of estrogen replacement therapy (ERT). Patients who were constantly treated with ERT showed higher bone mineral density (BMD) at the lumbar spine and femoral neck (p=0.026 and p=0.040, respectively) and TBS (p=0.031). The presence of metabolic diseases appeared to have a negative influence on TBS (p=0.034). DISCUSSION: Regular ERT and longer treatment duration appear to be the most important factors to significantly improve BMD and TBS levels in patients with TS. On the contrary, diagnosis of metabolic diseases significantly affect bone microarchitecture.

conclusionHealthcare providers should pay particular attention to timely ERT and the prevention of metabolic complications, since these are the main factors that appear to improve bone architecture in this specific population.

Indexed as

Bone DensityCancellous BoneEstrogen Replacement TherapyTurner SyndromeAdolescentAdultFemaleFemur NeckHumansLumbar VertebraeRetrospective StudiesYoung Adultbone fragilitybone microarchitecturecongenital diseaseestrogen replacement therapytrabecular bone scoreTurner syndrome

Identifiers

PMID42750434
PMCPMC13595327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.