ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Rapid-Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Electrochemical point-of-care testing for complex clinical samples is frequently hampered by matrix interference, signal instability, and laborious electrode modification procedures. Herein, we report a magnetic portable electrochemical immunosensor utilizing a conductive, anti-fouling hydrogel coating composed of sodium alginate, polyethylene glycol, and graphene (SPG). Upon calcium-ion triggering, the SPG solution forms a stable electrode hydrogel coating within 1 min, effectively resisting nonspecific adsorption while maintaining low‑impedance electron transfer. Guided by a 3D-printed magnetic apparatus, the MpECis directly captures target-bound magnetic complexes, enabling rapid enrichment and electrical readout within 25 min. By implementing time‑domain averaging over the enzymatic reaction plateau, the coefficient of variation of electrical signals generated by nanoenzyme catalysis was reduced to 3.4%, markedly improving measurement reproducibility. The clinical practicality of the SPG MpECis platform was validated through three independent cohorts, including detection of cardiac troponin I in 59 serum samples, quantification of extracellular vesicles in 47 plasma samples, and detection of C-reactive protein in 17 fingertip blood samples. Compared with the reference method, the area under the curve of this method are 0.99, 0.93, and 1.00, respectively. This platform offers a practical route for stable electrochemical diagnostics in complex biological matrices and home-based precision medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.