Evidence map›Paper›PMID 42750214›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures.

Ian Engels, Tristan Dedrie, Synnøve K Mo, Simon Van de Vyver, Thijs R A Vandenbroucke, Kévin Di Modíca, Jan Decher, Alice Toso, Dieter Deforce, Simon Daled and 3 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ian EngelsLaboratory of Pharmaceutical Biotechnology, ProGenTomics, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0009-0003-1059-7541
Tristan DedrieArcheOs Laboratory for Biological Anthropology, Department of Archaeology, Faculty of Arts and Philosophy, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0001-7536-8668
Synnøve K MoDepartment of Geology, Faculty of Sciences, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0009-0008-3972-8417
Simon Van de VyverDepartment of Mathematics, Statistics and Computer Science, Faculty of Sciences, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0009-0009-7810-2174
Thijs R A VandenbrouckeDepartment of Geology, Faculty of Sciences, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-8182-3708
Kévin Di ModícaScladina Cave Archaeological Centre, Espace muséal d'Andenne, Andenne, Belgium.ORCID https://orcid.org/0000-0001-5067-5805
Jan DecherLeibniz-Institut Zur Analyse Des Biodiversitätswandels (LIB), Museum Koenig Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0003-3941-0659
Alice TosoBonn Center For ArchaeoSciences, Institut Für Archäologie und Kulturanthropologie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.ORCID https://orcid.org/0000-0003-3469-1412
Dieter DeforceLaboratory of Pharmaceutical Biotechnology, ProGenTomics, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-0635-661X
Simon DaledLaboratory of Pharmaceutical Biotechnology, ProGenTomics, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0001-8129-2217
Alexandra BurnettLaboratory of Pharmaceutical Biotechnology, ProGenTomics, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-2810-0500
Grégory AbramsArcheOs Laboratory for Biological Anthropology, Department of Archaeology, Faculty of Arts and Philosophy, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-0616-4335
Maarten DhaenensLaboratory of Pharmaceutical Biotechnology, ProGenTomics, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-9801-3509

Funding

Research Foundation Flanders (FWO) 1176726NResearch Foundation Flanders (FWO) 11Q0H24NResearch Foundation Flanders (FWO) 12A9Q26NResearch Foundation Flanders (FWO) G0C1523NSpecial Research Fund (BOF), Ghent University BOF.GOA.2022.0002.03Special Research Fund (BOF), Ghent University BOF.PDO.2025.003
6 · The paper itself

Abstract

Species identification in palaeoproteomics relies on genome-derived protein sequences which are often poor-quality, and lacks tools to cope with multi-species samples. Here, we address both challenges through the analysis of "physical and genetic mixtures". Species that are absent from our database are considered a "genetic mixture", i.e. a patchwork of peptides from closely related species. Inversely, various overlapping peptide stretches allow us to resolve complex "physical mixtures". This is benchmarked by analysing physical mixtures of modern bone fragments, including genetic mixtures. We illustrate the impact of our approach via a rapid and high-throughput analysis of >2500 bone fragments, revealing the Eemian-era faunal environment around Scladina Cave, including the first Palaeoloxodon antiquus identified at this site.

Indexed as

bioarchaeologybioinformaticscollagenpalaeontologypalaeoproteomics

Identifiers

PMID42750214
PMCPMC13583091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.