An ATP-Driven N Protein-DDX21 Molecular Switch Dynamically Controls SARS-CoV-2 RNA G-Quadruplex Heterogeneity.

Ya-Ting Zheng, Li-Yan Zhai, Jie Jin, Qiu-Ying Chen, Hang Fu, Xue-Qian Sun, Ying Lu, Hui Li, Xi-Miao Hou

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ya-Ting Zheng *College of Life Sciences, Northwest A&F University, Shaanxi, China.

Li-Yan Zhai *College of Life Sciences, Northwest A&F University, Shaanxi, China.

Jie JinCollege of Life Sciences, Northwest A&F University, Shaanxi, China.

Qiu-Ying ChenCollege of Life Sciences, Northwest A&F University, Shaanxi, China.

Hang FuBeijing National Laboratory For Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-0213-7396

Xue-Qian SunBeijing National Laboratory For Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.

Ying LuBeijing National Laboratory For Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-8421-7228

Hui LiSchool of Systems Science and Institute of Nonequilibrium Systems, Beijing Normal University, Beijing, China.ORCID https://orcid.org/0000-0003-0551-9912

Xi-Miao HouCollege of Life Sciences, Northwest A&F University, Shaanxi, China.ORCID https://orcid.org/0000-0003-3499-443X

Funding

Frontier Interdisciplinary Innovation Project of the Future Agriculture Research Institute, Northwest A&F University A1080525005National Natural Science Foundation of China 32571440

6 · The paper itself

Abstract

The SARS-CoV-2 RNA genome functions as a highly structured regulatory scaffold. Although bioinformatic analyses predict widespread RNA G-quadruplexes (G4s) across the viral genome, their structural diversity and regulatory mechanisms remain poorly understood. Here, we report a diverse landscape of viral G4s encompassing parallel and non-canonical topologies with remarkable thermostability. Unlike typical eukaryotic G4s, these two-tetrad viral G4s exhibit a hierarchical ion-dependent mechanism, in which K

Indexed as

DEAD‐box helicasesG‐quadruplexheterogeneitynucleocapsid proteinSARS‐CoV‐2

Identifiers

PMID42750138

DOI10.1002/advs.77748

PMCPMC13583083

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.