Evidence map›Paper›PMID 42750107›Full record

ArticleJournal of internal medicine2026

A demographic perspective on longevity and healthspan: Rethinking population ageing through a positive and prospective lens.

Daniele Vignoli, Cosmo Strozza, Agar Brugiavini, Davide Liborio Vetrano, Amaia Calderón-Larrañaga, Serhiy Dekhtyar, Pietro Grassi, Chiara Seghieri

Abstract read
In one paragraph

Article in Journal of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniele VignoliDepartment of Statistics, Computer Sciences, Applications, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-1227-5880
Cosmo StrozzaInterdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0001-8825-2971
Agar BrugiaviniDepartment of Economics, University of Venice Ca Foscari, Venice, Italy.ORCID https://orcid.org/0000-0002-5871-2575
Davide Liborio VetranoAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3099-4830
Amaia Calderón-LarrañagaAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-9064-9222
Serhiy DekhtyarAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3062-4848
Pietro GrassiInstitute of Management, L'EMbeDS, Sant'Anna School of Advanced Studies, Pisa, Italy.ORCID https://orcid.org/0009-0006-5569-4398
Chiara SeghieriInstitute of Management, L'EMbeDS, Sant'Anna School of Advanced Studies, Pisa, Italy.ORCID https://orcid.org/0000-0002-3910-7775

Funding

European Union-Next Generation EU PE8-B83C22004800006
6 · The paper itself

Abstract

Population ageing is portrayed as a threat to the sustainability of health and welfare systems. This narrative-grounded in static chronological definitions of old age-risks overstating the burden of increasing longevity while overlooking changes in survival, health and population composition. In this article, we adopt a demographic perspective to rethink longevity and healthspan through the lens of positive demography, which reframes ageing as a structural transformation that can generate opportunities if institutions, health systems and policies adapt accordingly. Using prospective measures that define old age by remaining life expectancy (LE), we show that population ageing appears less burdensome than conventional indicators suggest (e.g., dynamic dependency ratios fluctuate around 20% compared with 40% under fixed thresholds). Nonetheless, challenges persist, including growing heterogeneity and inequalities in late-life health and care needs (with healthcare workforce demand by 2071 ranging from a 33% increase to a 16% decrease depending on morbidity trends) and a widening gap between lifespan and healthspan (LE at age 60 has risen at double the rate of healthy LE), resulting in more prolonged dependency and complex end-of-life trajectories. Prevention (primordial, primary, secondary and tertiary) and palliative care emerge as crucial but insufficiently integrated components of ageing societies' health systems. We conclude that a forward-looking demographic framework-integrating dynamic age thresholds, cohort-specific health profiles, and equitable access to care across the full continuum-is essential to align societies with realities of longer lives. Population ageing is not a problem to be solved but a context within which health systems and policies must evolve.

Indexed as

AgingDemographyLife ExpectancyLongevityAgedHumansPopulation DynamicsProspective Studieshealthspanlongevitypalliative carepopulation ageingpositive demographyprospective age

Identifiers

PMID42750107
PMCPMC13641284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.