Evidence map›Paper›PMID 42749933›Full record

ArticleEuropean journal of pediatrics2026

Prevention of post-natal acquisition of neonatal herpes: evaluation of an educational tool for pregnant women compared to routine prenatal care.

Audrey Pontrucher, Olivier Picone, Anne-Gaël Cordier, Constance Borie, Karine Pattier, Florence Biquard, Marie-Benjamine Hardy, Mathieu Maingon, Eloïse Bertrand, Christelle Vauloup-Fellous and 1 more

Abstract readComparative StudyControlled Clinical TrialMulticenter Study
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In one paragraph

Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Audrey PontrucherDepartment of Virology, Angers University Hospital, 4 Rue Larrey, 49933 , Angers, France.
Olivier PiconeDepartment of Obstetrics and Gynecology, Louis Mourier Hospital (AP-HP), Colombes, France.
Anne-Gaël CordierGroupe de Recherche Sur Les Infections Pendant La Grossesse (GRIG), Paris, France.
Constance BorieGroupe de Recherche Sur Les Infections Pendant La Grossesse (GRIG), Paris, France.
Karine PattierDivision of Obstetrics and Gynecology, Centre Hospitalier Saint-Julien, Château-Gontier, France.
Florence BiquardDepartment of Obstetrics and Gynecology, Angers University Hospital, Angers, France.
Marie-Benjamine HardyDivision of Paediatric Critical Care and Neonatal Medicine, Angers University Hospital, Angers, France.
Mathieu MaingonDepartment of Virology, Angers University Hospital, 4 Rue Larrey, 49933 , Angers, France.
Eloïse BertrandDepartment of Virology, Angers University Hospital, 4 Rue Larrey, 49933 , Angers, France.
Christelle Vauloup-FellousGroupe de Recherche Sur Les Infections Pendant La Grossesse (GRIG), Paris, France.
Elise BouthryDepartment of Virology, Angers University Hospital, 4 Rue Larrey, 49933 , Angers, France. elise.bouthry@chu-angers.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal herpes is a rare but severe viral infection. In France, recent data indicate a shift toward predominantly postnatal transmission, contrary to earlier literature which primarily reported perinatal cases. Unlike perinatal herpes, specific guidelines for preventing postnatally acquired neonatal herpes (PNH) are lacking, despite it being largely preventable through basic hygiene. Consequently, an educational tool (ET) was developed to inform pregnant women. This study aims. to evaluate the association between the ET and pregnant women's knowledge regarding PNH prevention, and to assess its acceptability among patients and healthcare professionals (HPs). In this prospective multicentric study, a PNH questionnaire was distributed to women during postpartum hospitalization. Based on self-reported exposure during routine prenatal care, participants were categorized into an unexposed control group (Group 1, n = 500) and an ET-exposed group (Group 2, n = 200). Baseline knowledge was limited: in Group 1, 38.6% of women were unaware of transmission via cold sores, and 70.5% ignored the infection's potential severity. Exposure to the ET (Group 2) was associated with significantly higher knowledge scores regarding transmission routes and preventive measures compared to Group 1 (e.g., p < 0.001). Exposed women reported high motivation to implement preventive behaviors (94.5%) and promote them within their families (98.0%). Among participating HPs, the ET was deemed highly adapted to their patients, with 92.3% intending continued use.

conclusionsMaternal knowledge regarding PNH transmission and prevention remains limited but can be improved through targeted education. Integrating a low-cost, accessible ET into routine prenatal care effectively raises awareness. WHAT IS KNOWN: • Neonatal herpes is increasingly acquired postnatally, yet there is a marked lack of awareness regarding postnatally acquired neonatal herpes (PNH) and its prevention. • It is preventable through simple hygiene, yet maternal awareness remains critically low. WHAT IS NEW: • An educational tool (ET) is associated with enhanced knowledge among pregnant women regarding PNH preventive strategies. • The tool highly motivates mothers to implement household-wide hygiene measures.

Indexed as

Health Knowledge, Attitudes, PracticeHerpes SimplexInfectious Disease Transmission, VerticalPatient Education as TopicPregnancy Complications, InfectiousPrenatal CareAdultFemaleFranceHumansInfant, NewbornPregnancyProspective StudiesSurveys and QuestionnairesYoung AdultEducational toolKnowledgeNeonatal herpesPostnatal herpesPregnancyPrevention

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.