Evidence map›Paper›PMID 42749878›Full record

ArticleExperimental & molecular medicine2026

A refined MASH-HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression.

Hyunmi Kim, Gyeonghun Kim, Hyojin Yeon, Da-Yeon Yang, Sang Gyu Lee, Tae Hyeon An, Seung Yeon Oh, Seona Yoon, Jiwoo Kim, Juyong Choi and 13 more

Abstract read
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In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hyunmi Kim *Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Gyeonghun Kim *Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Hyojin YeonDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Da-Yeon YangMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Sang Gyu LeeLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Tae Hyeon AnMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Seung Yeon OhLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Seona YoonKorea Model animal Priority Center, Seoul National University, Seoul, Republic of Korea.
Jiwoo KimDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Juyong ChoiMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Hyun-Ju ParkMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Eun-Woo LeeMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-5156-0003
Baek-Soo HanDepartment of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Republic of Korea.
Chul-Ho LeeDepartment of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-6996-5746
Il Yong KimLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Won Kon KimMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Kwang-Hee BaeMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-5868-2556
Jun Won ParkLaboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Seung Hyun OhLaboratory of Veterinary Histology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Young Nyun ParkDepartment of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-0357-7967
Murim ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-9195-1455
Je Kyung SeongLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. snumouse@snu.ac.kr.ORCID http://orcid.org/0000-0003-1177-6958
Kyoung-Jin OhMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea. kjoh80@kribb.re.kr.ORCID http://orcid.org/0000-0002-2224-7202

Funding

Korea Research Institute of Bioscience and Biotechnology (KRIBB) KGM5392622National Research Foundation of Korea (NRF) 2020R1A2C2102308National Research Foundation of Korea (NRF) RS-2024-00400118National Research Foundation of Korea (NRF) RS-2025-00522077
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading driver of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking metabolic stress, chronic inflammation and tumorigenesis remain poorly understood. Here we established a metabolically relevant, time-efficient MASH-to-HCC model in C57BL/6N mice by combining a MASH diet with controlled CCl

Indexed as

Antigens, DifferentiationCarcinoma, HepatocellularInflammationLiver NeoplasmsMacrophagesAnimalsDisease Models, AnimalDisease ProgressionGADD45 ProteinsGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred C57BLAntigens, DifferentiationGADD45B protein, humanGadd45b protein, mouseGADD45 Proteins

Identifiers

PMID42749878

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.