Evidence map›Paper›PMID 42749843›Full record

ArticleMolecular genetics and genomics : MGG2026

USP22 alleviates oxidative stress-induced BMSCs senescence by stabilizing SPI1 protein.

Min Wu, Yi-Fei Yang, Xiang-Ping Du

Abstract read
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In one paragraph

Article in Molecular genetics and genomics : MGG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Min WuDepartment of Orthopedics, Jiangxi Provincial Children's Hospital, No. 1666 Diezihu Avenue, Honggutan New District, Nanchang, 330038, Jiangxi Province, China. 436999189@139.com.
Yi-Fei YangDepartment of Orthopedics, Jiangxi Provincial Children's Hospital, No. 1666 Diezihu Avenue, Honggutan New District, Nanchang, 330038, Jiangxi Province, China.
Xiang-Ping DuDepartment of Orthopedics, Jiangxi Provincial Children's Hospital, No. 1666 Diezihu Avenue, Honggutan New District, Nanchang, 330038, Jiangxi Province, China.

Funding

Jiangxi Provincial Health Commission Science and Technology Program Project Grant No. 202610806Qingmiao Research Project of Jiangxi Provincial Children's Hospital Grant No. 2025JXEYQM01
6 · The paper itself

Abstract

backgroundTherapeutic efficacy of bone marrow mesenchymal stem cell (BMSC) transplantation is often compromised by cellular senescence and diminished osteogenic potential induced by oxidative stress. Nevertheless, the underlying molecular mechanisms remain poorly understood. This study explores the role of ubiquitin-specific peptidase 22 (USP22) in regulating oxidative stress-induced BMSCs senescence.

methodsBMSCs were exposed to H

resultsSPI1 expression declined in H

conclusionUSP22 mitigated oxidative stress-induced BMSCs senescence and preserved osteogenic capacity by promoting NAMPT transcription through deubiquitinating and stabilizing SPI1 protein.

Indexed as

Cellular SenescenceMesenchymal Stem CellsOxidative StressTrans-ActivatorsUbiquitin ThiolesteraseAnimalsCell DifferentiationFemaleHumansHydrogen PeroxideOsteogenesisOsteoporosisRatsRats, Sprague-DawleyUbiquitinationHydrogen PeroxideTrans-ActivatorsUbiquitin ThiolesteraseUsp22 protein, humanBone marrow mesenchymal stem cellsNAMPTOxidative stressSenescenceSPI1USP22

Identifiers

PMID42749843

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.