Evidence map›Paper›PMID 42749800›Full record

ArticleNature2026

Topographic structure and function of locus coeruleus noradrenaline neurons.

Zhixiao Su, Polina Kosillo, Kanghoon Jung, Shuonan Chen, Mathew T Summers, Alex Piet, Han Hou, Kenta M Hagihara, Drew Friedmann, Olivia Ho-Shing and 45 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

55 authors.

Zhixiao SuAllen Institute, Neural Dynamics, Seattle, WA, USA.
Polina KosilloAllen Institute, Neural Dynamics, Seattle, WA, USA.
Kanghoon JungAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5381-5161
Shuonan ChenAllen Institute, Neural Dynamics, Seattle, WA, USA.
Mathew T SummersAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0009-0002-3409-7384
Alex PietAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6529-1414
Han HouAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4590-7891
Kenta M HagiharaAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0064-0852
Drew FriedmannAllen Institute, Neural Dynamics, Seattle, WA, USA.
Olivia Ho-ShingAllen Institute, Neural Dynamics, Seattle, WA, USA.
Matthew I BeckerAllen Institute, Neural Dynamics, Seattle, WA, USA.
Thomas ChartrandAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7093-8681
Xinxin YinAllen Institute, Neural Dynamics, Seattle, WA, USA.
Peter GrotzAllen Institute, Neural Dynamics, Seattle, WA, USA.
Ella Hilton-VanOsdallAllen Institute, Neural Dynamics, Seattle, WA, USA.
Margaret LeeAllen Institute, Neural Dynamics, Seattle, WA, USA.
Rajvi JaveriAllen Institute, Neural Dynamics, Seattle, WA, USA.
Samantha L TuggleAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1442-8238
Naveen OuelletteAllen Institute, Neural Dynamics, Seattle, WA, USA.
Holly MyersAllen Institute, Neural Dynamics, Seattle, WA, USA.
Judith BakaAllen Institute, Neural Dynamics, Seattle, WA, USA.
Camilo LaitonAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8488-8753
Kaelin WulfAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0009-0008-8394-8900
John RohdeAllen Institute, Neural Dynamics, Seattle, WA, USA.
Alessio P BuccinoAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3661-527X
Cameron ArshadiAllen Institute, Neural Dynamics, Seattle, WA, USA.
Di WangAllen Institute, Neural Dynamics, Seattle, WA, USA.
Sharmishtaa SeshamaniAllen Institute, Neural Dynamics, Seattle, WA, USA.
Sonya VasquezAllen Institute, Neural Dynamics, Seattle, WA, USA.
Carolyn M EngAllen Institute, Neural Dynamics, Seattle, WA, USA.
Douglas R OllerenshawAllen Institute, Neural Dynamics, Seattle, WA, USA.
Nick DeeAllen Institute, Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2831-9254
Tamara CasperAllen Institute, Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1638-3651
Windy HoAllen Institute, Brain Science, Seattle, WA, USA.
Matthew JungertAllen Institute, Brain Science, Seattle, WA, USA.
Atlas JordanAllen Institute, Brain Science, Seattle, WA, USA.
Elliot PhillipsAllen Institute, Brain Science, Seattle, WA, USA.
Anish Bhaswanth ChakkaAllen Institute, Brain Science, Seattle, WA, USA.
Kamiliam NasirovaAllen Institute, Brain Science, Seattle, WA, USA.
Krista BlakeAllen Institute, Brain Science, Seattle, WA, USA.
Audrey McCutcheonAllen Institute, Brain Science, Seattle, WA, USA.
Megan KochAllen Institute, Brain Science, Seattle, WA, USA.
Maria Camila VergaraAllen Institute, Brain Science, Seattle, WA, USA.
Kimberly A SmithAllen Institute, Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3142-1970
Tim JarskyAllen Institute, Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4399-539X
Nicholas LuskAllen Institute, Brain Science, Seattle, WA, USA.
Mara C P RueAllen Institute, Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4305-7838
Xiaoyin ChenAllen Institute, Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2807-6125
Joshua H SiegleAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7736-4844
Adam K GlaserAllen Institute, Neural Dynamics, Seattle, WA, USA.
Brian R LeeAllen Institute, Brain Science, Seattle, WA, USA.
Karel SvobodaAllen Institute, Neural Dynamics, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6670-7362
Yoh IsogaiAllen Institute, Neural Dynamics, Seattle, WA, USA. yoh.isogai@alleninstitute.org.ORCID http://orcid.org/0000-0001-7285-1603
Jayaram V ChandrashekarAllen Institute, Neural Dynamics, Seattle, WA, USA. jayaramc@alleninstitute.org.ORCID http://orcid.org/0000-0001-6412-0114
Jeremiah Y CohenAllen Institute, Neural Dynamics, Seattle, WA, USA. jeremiah.cohen@alleninstitute.org.ORCID http://orcid.org/0000-0002-4768-7124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noradrenaline (also known as norepinephrine) is released throughout most of the central nervous system by neurons in the locus coeruleus

Identifiers

PMID42749800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.