Evidence map›Paper›PMID 42749790›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Whole genome sequencing reveals a specific microbiota in subglottic stenosis C. acnes may contribute to inflammation.

Anders Erlandsson, Stina Chorell, Anne Tuiskunen Bäck, Linda Köhn, Michael Haney, Katarina Olofsson

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Anders Erlandsson *Department of Clinical Sciences, Otorhinolaryngology, Umeå University, Umeå, 901 89, Sweden. anders.erlandsson@umu.se.ORCID http://orcid.org/0000-0001-8082-4357
Stina Chorell *Department of Clinical Sciences, Otorhinolaryngology, Umeå University, Centre for Research and Development, Uppsala University/Region Gävleborg, Gävle, Sweden.ORCID http://orcid.org/0009-0009-0404-6982
Anne Tuiskunen BäckDepartment of Clinical Microbiology, Umeå university, Umeå, Sweden.ORCID http://orcid.org/0000-0001-9821-1348
Linda KöhnDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-2145-9385
Michael HaneyDepartment of Diagnostics and Intervention, Anaesthesiology and Intensive care, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-4049-8910
Katarina OlofssonDepartment of Clinical Sciences, Otorhinolaryngology, Sunderby Research Unit-Norrbotten, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-0649-3825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSubglottic stenosis (SGS) progressively reduces the airway below the vocal folds. The cause is not known and there is a recurrent need of surgical treatment. Including all phenotypes, SGS affects 1/400 000/yr, with a female dominance. Previous studies have revealed a possible role of the Mycobacterium complex in SGS development. Our hypothesis is that microbiota is associated with the inflammation in SGS, if true it might affect the prevailing treatment options.

methodsThis prospective cross-sectional study included biopsies from 34 patients with subglottic stenosis, collected between 2020 and 2023. Nucleic acids were extracted from the tissue samples and analysed using whole genome sequencing. Microbial composition was characterized using taxonomic profiling of sequencing data. Species with sufficient read counts were selected for further validation using sequence alignment methods to ensure accuracy of identification.

resultsUsing the most comprehensive form of genomic testing currently in clinical use, we present curated and stable data on the presence of Cutibacterium acnes in 28 out of the 34 cases.

conclusionCutibacterium acnes may serve as a driver of the inflammation characterizing SGS and should be considered in therapeutically oriented future studies. LEVEL OF EVIDENCE: 4:

Indexed as

Cutibacterium acnesLaryngotracheal stenosisSubglottic stenosisWhole genome sequencing

Identifiers

PMID42749790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.