Evidence map›Paper›PMID 42749776›Full record

ArticleMolecular psychiatry2026

Persistent tic disorders are associated with 17q12 duplications.

Matthew W Halvorsen, Sheng Wang, Tyne W Miller-Fleming, Dongmei Yu, Apostolia Topaloudi, Elles de Schipper, Julia Bäckman, David Mataix-Cols, Christian Rück, Behrang Mahjani and 24 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Matthew W Halvorsen *Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. mhalvors@email.unc.edu.ORCID http://orcid.org/0000-0002-6707-2418
Sheng Wang *Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94143, USA.
Tyne W Miller-FlemingDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Dongmei YuPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7901-4365
Apostolia TopaloudiDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Elles de SchipperCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.
Julia BäckmanCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.
David Mataix-ColsCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4545-0924
Christian RückCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8742-0168
Behrang MahjaniDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6087-9537
Joseph D BuxbaumDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8898-8313
Dorothy E GriceDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8833-2549
Larisa H CavallariDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, FL, USA.
Dominick J AngiolilloDepartment of Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, FL, USA.
Francesco FranchiDepartment of Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, FL, USA.
Lea K DavisDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
Lide HanDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0132-2656
Douglas M RuderferDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Psychiatric Genomics Consortium OCD-TS Working Group (PGC-OCD-TS)
TS-EUROTRAIN
EMTICS
Tourette International Collaborative Genetics (TIC Genetics)
Tourette Association of America International Consortium of Genetics (TAAICG)
Nordic OCD and Related Disorders Consortium (NORDIC)
Andrea DietrichDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1018-9954
Manuel MattheisenDalhousie University, Department of Community Health and Epidemiology & Faculty of Computer Science, Halifax, Nova Scotia, Canada.ORCID http://orcid.org/0000-0002-8442-493X
Luz M PorrasDepartment of Psychiatry, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-0162-4494
Paola Giusti-RodriguezDepartment of Psychiatry, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-1921-1305
Carol A MathewsDepartment of Psychiatry, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-2208-7058
Peristera PaschouDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-9783-1024
Jeremiah M ScharfPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
A Jeremy WillseyDepartment of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94143, USA.
James J CrowleyDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9051-1557

Funding

Large-Scale Collaborative Genetic and Epigenetic Studies of Tourette SyndromeR01NS105746 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATHEWS, CAROL A, PASCHOU, PERISTERA · 2019 to 2023
$3.1M
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01NS105746
6 · The paper itself

Abstract

Tourette Syndrome (TS) and Persistent Tic Disorder (PTD) are childhood-onset neuropsychiatric conditions with high heritability. Due to current sample size limitations, identifying TS/PTD risk genes has been challenging. This study addressed this issue by conducting a meta-analysis of microarray copy number variant (CNV) studies from three TS/PTD genomics consortia, supplemented with new data from 3291 cases. This approach more than doubled the sample size of previous TS/PTD CNV studies, with CNV calls generated from 5725 TS/PTD cases and 10,982 matched controls. The results confirmed that TS/PTD cases 1) have a higher burden of ultra-rare deletions overlapping loss-of-function intolerant genes (OR = 1.68, P = 9.3×10

Identifiers

PMID42749776

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.