Evidence map›Paper›PMID 42749736›Full record

Trial reportNature communications2026

Diagnostic performance and antibiotic impact of droplet digital PCR in suspected sepsis: the PROGRESS trial.

Haocheng Zhang, Ke Lin, Xinlei Xu, Qiaoyan Yue, Xiang Li, Xiaohua Chen, Liang Hong, Lina Chen, Yan Huang, Ying Ye and 21 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Haocheng Zhang *Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Ke Lin *Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Xinlei Xu *Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Qiaoyan Yue *Department of Infectious Disease, Nanjing Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China.
Xiang LiDepartment of Infectious Disease, Minhang Hospital, Shanghai, China.
Xiaohua ChenDepartment of Infectious Disease, Shanghai Sixth People's Hospital, Shanghai, China.
Liang HongDepartment of Infectious Disease, Ruian People's Hospital, Wenzhou, Zhejiang, China.
Lina ChenDepartment of Infectious Disease, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yan HuangDepartment of Infectious Disease, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ying YeDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Tingting SuDepartment of Infectious Disease, Wuxi Fifth People's Hospital, Wuxi, Jiangsu, China.
Jingye PanDepartment of Infectious Disease, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Weiqin LiDepartment of Infectious Disease, Jinling Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, China.
Shuang XiaoDepartment of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiaoxia GengDepartment of Infectious Disease, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Jingjing ZhengDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Lijing JiangDepartment of Infectious Disease, Minhang Hospital, Shanghai, China.
Jie ChenDepartment of Infectious Disease, Shanghai Sixth People's Hospital, Shanghai, China.
Shengguo ZhangDepartment of Infectious Disease, Ruian People's Hospital, Wenzhou, Zhejiang, China.
Yadi LiuDepartment of Infectious Disease, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Liang LiDepartment of Infectious Disease, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jun YinDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Hejuan DuDepartment of Infectious Disease, Wuxi Fifth People's Hospital, Wuxi, Jiangsu, China.
Aiming ZhouDepartment of Infectious Disease, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lu KeDepartment of Infectious Disease, Jinling Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, China.ORCID 0000-0001-8093-5073
Qiuping HuangDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Li ChenDepartment of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ting FengDepartment of Infectious Disease, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Ruilan WangDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. wangyusun@hotmail.com.
Jingwen AiDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. jingwenai@fudan.edu.cn.
Wenhong ZhangDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. zhangwenhong@fudan.edu.cn.ORCID 0000-0002-1246-0747

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, tools to dynamically monitor pathogen load and guide antibiotic adjustment in suspected sepsis are limited. In this prospective, multicenter randomized trial (3:1, ddPCR vs standard care), 1,373 patients were followed for 90 days. The primary outcome was diagnostic efficacy; secondary outcomes included mortality and SOFA. ddPCR showed higher detection positivity (54.1% vs 21.6%, p < 2 × 10

Indexed as

Anti-Bacterial AgentsPolymerase Chain ReactionSepsisAgedBacterial LoadFemaleHumansMaleProspective StudiesSensitivity and SpecificityAnti-Bacterial Agents

Identifiers

PMID42749736
PMCPMC13582850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.