Evidence map›Paper›PMID 42749722›Full record

ArticleNature communications2026

Molecular arrangement and modulation of extrasynaptic αβδ GABA

Stephanie A Nestorow, Wan-Na Chen, Daniel Bertrand, Ayla A Wahid, Caroline E Wyatt, Martin Mortensen, Thomas Clairfeuille, Michael Reutlinger, Gregoire Friz, Els Pardon and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stephanie A NestorowDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Wan-Na ChenDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Daniel BertrandHiQScreen Sàrl, 6, rte de Compois, 1222 Vésenaz, Geneva, Switzerland.ORCID 0000-0003-2057-7133
Ayla A WahidDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8128-9632
Caroline E WyattDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Martin MortensenDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID 0000-0002-5873-7107
Thomas ClairfeuilleRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, Basel, Switzerland.
Michael ReutlingerRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, Basel, Switzerland.ORCID 0000-0001-9393-108X
Gregoire FrizRoche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland.
Els PardonStructural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID 0000-0002-2466-0172
Jan SteyaertStructural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID 0000-0002-3825-874X
Graham LaddsDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7320-9612
Giuseppe CecereRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, Basel, Switzerland.ORCID 0000-0001-5004-8932
Trevor G SmartDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID 0000-0002-9089-5375
Maria-Clemencia HernandezRoche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland.ORCID 0000-0003-1621-4188
Lisa JoedickeRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, Basel, Switzerland. lisa.joedicke@roche.com.
Paul S MillerDepartment of Pharmacology, University of Cambridge, Cambridge, UK. pm676@cam.ac.uk.ORCID 0000-0002-6512-9441

Funding

Medical Research Council MR/T002581/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M024709/1
6 · The paper itself

Abstract

γ-aminobutyric acid Type-A (GABA

Indexed as

Receptors, GABA-AAllosteric RegulationAnimalsBinding SitesCryoelectron Microscopygamma-Aminobutyric AcidHumansModels, MolecularProtein Subunitsgamma-Aminobutyric AcidProtein SubunitsReceptors, GABA-A

Identifiers

PMID42749722
PMCPMC13582853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.