Evidence map›Paper›PMID 42749715›Full record

ArticleNature communications2026

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates.

Damien Glon, Quentin Riller, Lucía Álvarez, Louise Gioja, Frédéric Rivière, Benjamin Léonardon, Zackie Aktary, Ariane Guillemot, Laïla Sago, Olivier Pellé and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Damien GlonInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France. damien.glon@i2bc.paris-saclay.fr.ORCID 0000-0001-8405-8805
Quentin Riller *Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.ORCID 0000-0003-3323-0235
Lucía Álvarez *Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID 0000-0002-1437-5773
Louise GiojaLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Frédéric RivièreInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Benjamin LéonardonInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID 0009-0005-9321-7034
Zackie AktaryInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Ariane GuillemotInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID 0009-0005-0540-7189
Laïla SagoInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Olivier PelléLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.ORCID 0000-0002-0163-6487
Nhat-Duong HoLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Karine BrochardNephrology, Internal Medicine and Pediatric Hypertension, Children Hospital, Toulouse, France.
Camille BrunaudLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Luís SeabraLaboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.ORCID 0000-0002-4678-3026
Gillian I RiceDivision of Evolution Infection & Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0002-4223-0571
Vincent BondetTranslational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-6534-0984
Darragh DuffyTranslational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-8875-2308
Brigitte Bader-MeunierLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Marie-Louise FrémondLaboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.ORCID 0000-0002-2798-9141
Alice LepelleyDepartment of Paediatric Hematology-Immunology and Rheumatology, Necker-Enfants Malades Hospital, Assistance publique-hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0001-8656-7291
Yanick J CrowLaboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.ORCID 0000-0001-7211-7564
Maud TusseauCentre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France.
Alexandre BelotCentre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France.ORCID 0000-0003-4902-5332
Cécile Lagaudrière-GesbertInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Frédéric Rieux-LaucatLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.ORCID 0000-0001-7858-7866
Yves GaudinInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France. yves.gaudin@i2bc.paris-saclay.fr.ORCID 0000-0002-0122-2954

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-24-CE15-7522Fondation pour la Recherche Médicale (Foundation for Medical Research in France) EQU202103012746
6 · The paper itself

Abstract

TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form liquid condensates. We show that NAP1 condensates concentrate TBK1. Using NAP1

Indexed as

Adaptor Proteins, Signal TransducingInterferon-betaProtein Serine-Threonine KinasesAnimalsHEK293 CellsHumansPhosphorylationProtein BindingProtein Phosphatase 2Signal TransductionAdaptor Proteins, Signal TransducingInterferon-betaProtein Phosphatase 2Protein Serine-Threonine KinasesTBK1 protein, human

Identifiers

PMID42749715
PMCPMC13582825

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.