ReviewJournal, genetic engineering & biotechnology2026
Phytochemical insights and pharmacological advances of Lepidium sativum L. (garden cress): bridging traditional medicine and evidence-based therapeutics.
Review in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLepidium sativum L. is a medicinal plant in the Brassicaceae family that has been used for the production of food and medicine. Scientists are becoming interested in it because of its rich phytochemical profile and ethnomedical uses. Nonetheless, a comprehensive understanding of its conventional use, bioactive components, pharmacological actions, and therapeutic significance is still crucial.
objectiveThis review examines Lepidium sativum's traditional uses, phytochemical profile, pharmacological actions, and toxicological and safety considerations.
methodsA literature search was conducted via PubMed, Scopus, Web of Science, and Google Scholar. This review was conducted in accordance with SANRA, and the findings were synthesized qualitatively.
resultsThis review shows Lepidium sativum has a variety of pharmacological activities, including anti-inflammatory, analgesic, antimicrobial, antidiabetic, gastroprotective, hepatoprotective, nephroprotective, cardioprotective, neuroprotective, osteoprotective, wound-healing, reproductive, and anticancer effects. Bioactive components such as glucosinolates, alkaloids, phenolics, flavonoids, coumarins, and lignans are mostly responsible for these activities. These compounds affect cellular signaling, oxidative stress, inflammation, apoptosis, and metabolic pathways. Nevertheless, differences in phytochemical content, extraction techniques, dosage, bioavailability, and lack of standardization limit clinical translation. Traditional dosages of Lepidium sativum are usually harmless, but excessive doses or extended exposure to concentrated formulations may be harmful.
conclusionLepidium sativum is a promising multipurpose medicinal plant that combines traditional knowledge with contemporary pharmacological research. Phytochemical bioactives and biological effects enable its growth as a source of functional foods, nutraceuticals, and medicinal agents. To determine its therapeutic potential, more research on molecular pathways, safety assessment, and clinical validation is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.