ArticleJournal, genetic engineering & biotechnology2026
Evaluation of the Antifungal Effect of Lacticaseibacillus rhamnosus GG against Oral candidiasis in Healthy Sprague-Dawley Rats.
Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundConventional treatments for oral candidiasis face limitations due to rising antifungal resistance and long-term toxicity. Probiotics, particularly, have shown antifungal potential, but their effects on non-albicans species like Candida tropicalis are not well understood. This study evaluated the therapeutic efficacy of Lacticaseibacillus rhamnosus GG against Candidaalbicans and Candidatropicalis in a rat model.
methodsSprague-Dawley rats were immunosuppressed using dexamethasone (0.5 mg/L) and tetracycline (0.1% initially, then 0.01%) in drinking water. A fungal suspension (1 × 10
resultsL. rhamnosus GG significantly reduced C. albicans and C. tropicalis colonization in immunosuppressed rats, with greater effects against C. albicans. Probiotic administration maintained normal haematological and biochemical parameters, reduced tissue invasion, and modulated immune responses, as evidenced by changes in TLR2, TLR4, and Msp1/p75 expression. These findings support the antifungal and immunomodulatory potential of L. rhamnosus GG as a complementary therapy for oral candidiasis.
conclusionThe present study suggests that L. rhamnosus GG may contribute to the development of probiotic-based therapies as a potential adjuvant to antifungal therapy in oral candidiasis.
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