Evidence map›Paper›PMID 42749403›Full record

ArticleJournal, genetic engineering & biotechnology2026

The role of IL-6 -174C/G polymorphism in hepatitis B virus infection: a genetic association study.

Nawar B Abdulsahib, Ahmed S Khalaf, Maryam Dhary, Ragheed H Yousif, Ghassan M Sulaiman, Hamdoon A Mohammed, Majid S Jabir, Khaled Haidar, Akram B Sultan

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Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Nawar B AbdulsahibDepartment of Biotechnology, College of Applied Sciences, University of Technology, Baghdad, Iraq. Electronic address: nawar.b.abdulsahib@uotechnology.edu.iq.
Ahmed S KhalafInstitute of Genetic Engineering and Biotechnology for Postgraduate Studies, University of Baghdad, Baghdad, Iraq.
Maryam DharyDepartment of Biotechnology, College of Applied Sciences, University of Technology, Baghdad, Iraq.
Ragheed H YousifDepartment of Biotechnology, College of Applied Sciences, University of Technology, Baghdad, Iraq.
Ghassan M SulaimanDepartment of Biotechnology, College of Applied Sciences, University of Technology, Baghdad, Iraq. Electronic address: ghassan.m.sulaiman@uotechnology.edu.iq.
Hamdoon A MohammedDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia.
Majid S JabirDepartment of Biotechnology, College of Applied Sciences, University of Technology, Baghdad, Iraq.
Khaled HaidarDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 67714, P.O. Box 255, Saudi Arabia.
Akram B SultanDepartment of Biology, College of Science, University of Bisha, Bisha 61922, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of the disease after infection with the hepatitis B virus (HBV) is linked to single-nucleotide polymorphisms (SNPs). SNPs' involvement in patients' persistent HBV infection is still unknown, though. Thus, the purpose of the current study was to assess the IL-6174C/G polymorphism in hepatitis B-infected Iraqi patients. The results revealed that serum HBV patients had higher levels of several interleukins, including IL-2, which exhibited a significant (P < 0.05) increase in individuals (237.04 ± 16.29 pg/mL) in comparison to the control group (115.42 ± 12.82 pg/mL). Serum IL-4 levels in HBV patients showed a substantial (P < 0.05) decrease as compared to healthy individuals (19.57 ± 1.63 pg/mL vs. 6.85 ± 0.53 pg/mL). When compared to the control group (13.44 ± 1.71 pg/mL), IL-6 levels showed a substantial (P < 0.05) increase in individuals (36.08 ± 1.67 pg/mL). For molecular study, in the patient hepatitis infection sample, the G allele was 65.6%, while the G allele in the control group was 31.1%. While the allele C in the sample of patients was 34.4%, compared to the allele T in the control group, which was 68.9%. The frequency of these genotypes among patients was 56.7%, 16.7%, and 26.6%, respectively, compared with 24.4%, 27.8%, and 47.8%, respectively, among controls. The frequency of GG varied significantly, according to statistics (OR = 0.21, 95% CI = 0.03-0.42, P = 0.001) and the CC genotype (OR = 1.63, 95% CI = 0.5-4.73, p = 0.031) between patients and controls. The mutant allele (allele G) was more common among patients than controls (65.6% vs. 31.1%) with a highly significant change (OR = 0.273, 95% CI = 0.31-0.13, p = 0.001).

Indexed as

CytokinesHepatitis BIL-6PolymorphismSNP

Identifiers

PMID42749403
PMCPMC13272513

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