Evidence map›Paper›PMID 42749401›Full record

ArticleJournal, genetic engineering & biotechnology2026

Bioactivity-guided evaluation of F7 fraction derived from Acalypha cuspidata on ovarian cancer models in vitro and in vivo.

Herrera-Martínez Mayra, Hernández-Ramírez Verónica Ivonne, Hernández-Carlos Beatriz, Talamás-Rohana Patricia

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Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Herrera-Martínez MayraInstitute of Pharmacobiology, University of the Cañada, Carretera Teotitlán - San Antonio Nanahuatipán Km 1.7 s/n., Paraje Titlacuatitla, Teotitlán of Flores Magón, 68540 Oaxaca, Mexico.
Hernández-Ramírez Verónica IvonneDepartment of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, Av. IPN No. 2508, San Pedro Zacatenco, Gustavo A. Madero 07360, CDMX, Mexico.
Hernández-Carlos BeatrizLaboratory of Natural Products, Institute of Agroindustry, Technological University of Mixteca, Av. Doctor Modesto Seara Vázquez No. 1, Acatlima, Huajuapan de León, 69000 Oaxaca, Mexico.
Talamás-Rohana PatriciaDepartment of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, Av. IPN No. 2508, San Pedro Zacatenco, Gustavo A. Madero 07360, CDMX, Mexico.. Electronic address: ptr@cinvestav.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on previous research, this study aimed to perform a bioactivity-guided evaluation of F7 fraction obtained from an ethyl acetate extract of Acalypha cuspidata (Jacq.) and to determine its anticancer activity on the SKOV-3 ovarian cancer cell line through in vitro and in vivo assays. Thus, ethyl acetate extract from A. cuspidata (9.8 g) was fractionated into 11 fractions (F1-F11) by open column chromatography, and chromatography-obtained fractions were evaluated using the WST-1 assay. Transmission electron microscopy, flow cytometry, Annexin V binding assay, and experimental model of the Nu / Nu mouse were carried out to analyze fraction 7 (F7) anti-tumor activity. The results showed that among the eleven fractions obtained, only F4 and F7 fractions showed lower cytotoxicity against SKOV-3 ovarian cancer cells and the best ability to selectively target cancer cells without affecting BEAS-2B non-cancer cell line. Toxicity data in primary culture of rat hepatocytes indicated that F7 fraction is less toxic than F4, hence, F7 was selected for further studies. F7 fraction (half maximal inhibitory concentration, IC

Indexed as

ApoptosisBioactivity-guided evaluationCell proliferationChromatographyHepatocytesMitochondrial damageSelectivity index

Identifiers

PMID42749401
PMCPMC13272508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.