Prognostic Factor Analysis for Risk-Stratified Papillary Thyroid Carcinoma and Nomogram Development for Predicting Structural Incomplete Response to Radioactive Iodine Therapy in Intermediate-Risk Patients.

Yamin Li, Zhaohui He, Min Zhao, Bin Zhang

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Article in Cancer reports (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Yamin LiDepartment of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0009-0005-8494-3771

Zhaohui HeDepartment of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.

Min ZhaoDepartment of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.

Bin ZhangDepartment of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0001-5305-2494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStructural incomplete response (SIR) after radioactive iodine (RAI) therapy indicates persistent or recurrent structural disease and has important implications for the long-term management of patients with papillary thyroid carcinoma (PTC). However, predictors of SIR across recurrence-risk strata remain incompletely characterized.

aimsTo identify factors associated with SIR following RAI therapy in risk-stratified PTC patients and to develop a predictive nomogram for intermediate-risk patients. METHODS AND

resultsWe retrospectively analyzed 615 PTC patients who underwent thyroidectomy, lymph-node dissection, and

conclusionsTg and LNM are key predictors of SIR in risk-stratified PTC patients. In this single-center retrospective cohort, the nomogram showed good discrimination and calibration for SIR in intermediate-risk patients; external multicenter validation is warranted before clinical application.

Indexed as

Iodine RadioisotopesNeoplasm Recurrence, LocalNomogramsThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedFemaleHumansLymphatic MetastasisLymph Node ExcisionMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentIodine RadioisotopesThyroglobulinLNMLNRnomogrampapillary thyroid carcinomaprognosissTg

Identifiers

PMID42748966

DOI10.1002/cnr2.70692

PMCPMC13581434

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