ArticleEchocardiography (Mount Kisco, N.Y.)2026
Left Atrial Volume Index, Left Ventricular Outflow Tract Gradient, and Incident Atrial Fibrillation in Hypertrophic Cardiomyopathy.
Article in Echocardiography (Mount Kisco, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAtrial fibrillation (AF) is a common complication of hypertrophic cardiomyopathy (HCM). Whether left atrial volume index (LAVI) or resting left ventricular outflow tract (LVOT) gradient better identifies patients who develop AF is unresolved.
objectivesTo compare baseline LAVI and resting LVOT gradient as predictors of incident AF in HCM.
methodsWe retrospectively studied 777 patients with HCM identified by ICD-10 code I42.1 (obstructive hypertrophic cardiomyopathy). Patients with pre-existing AF or atrial flutter were excluded, leaving 547 patients. The primary exposure was baseline LAVI (available in 167 patients; 25 incident AF events), analyzed per 10-mL/m
resultsDuring a median follow-up of 2.31 years, 60 patients developed incident AF. LAVI was independently associated with incident AF in the prespecified model adjusted for age, sex, and hypertension (adjusted HR per 10 mL/m
conclusionsIn HCM, LAVI and resting LVOT gradient were each independently associated with incident AF, and neither remained significant when modeled together. LAVI may serve as a practical echocardiographic marker to refine AF risk assessment.
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