Evidence map›Paper›PMID 42748655›Full record

ArticleRedox biology2026

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer's disease by chemically distinct air pollutants.

Kristina Shkirkova, Naomi S Sta Maria, Herbert Anson, Yashar Aghaei, Mohammad Mahdi Badami, Ararat Chakhoyan, Jose A Godoy-Lugo, Claire Chung, Salma Durra, Angela Tang-Tan and 23 more

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Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Kristina ShkirkovaKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Naomi S Sta MariaZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA; Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Herbert AnsonLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Yashar AghaeiViterbi School of Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
Mohammad Mahdi BadamiViterbi School of Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
Ararat ChakhoyanZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA; Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Jose A Godoy-LugoLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Claire ChungLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Salma DurraLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Angela Tang-TanKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Lifu ZhaoKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Alexandra DemetriouKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Manuel MoralesKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Sindhu DaggupatiKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Isabella BentKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Hyoungjin ParkKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Caleb FranklinKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Selena ChenKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Giovanni ChahineZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA; Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Skyye Dodds-LewisZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA; Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Masako MorishitaDepartment of Family Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Russell E JacobsZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA; Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Jean-François GoutDepartment of Biological Sciences, Mississippi State University, Starkville, MS, 39762, USA.
Wendy J MackPopulation and Public Health Sciences, Keck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Henry Jay FormanLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Marc VermulstLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Mitchell D CohenDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, 10016, USA.
Matthew CampenCollege of Pharmacy, University of New Mexico, Albuquerque, NM, 87106, USA.
Constantinos SioutasViterbi School of Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
William J MackKeck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
Caleb E FinchLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA; Dornsife College, University of Southern California, 3551 Trousdale Pkwy, Los Angeles, CA, 90089, USA.
Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA. Electronic address: thorwald@usc.edu.

Funding

Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
Amyloid and inflammation: modulation by apoE, gender, air pollution, and drugsRF1AG051521 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2015 to 2015
$3.0M
NIA NIH HHS P01 AG055367NIA NIH HHS RF1 AG051521
6 · The paper itself

Abstract

Air pollution (AirP) exposure is associated with increased risk of Alzheimer's disease (AD), yet AirP is chemically heterogeneous, complicating identification of shared pathogenic drivers. We compared acute cortical responses to two chemically distinct but metal-rich AirP sources, diesel exhaust particles (DEP) and World Trade Center (WTC) dust, and contrasted them with woodsmoke (WS), a particulate exposure containing substantially lower metal content. Despite major differences in particle composition and size, DEP and WTC elicited highly convergent transcriptomic responses, sharing more than 1200 differentially expressed genes associated with oxidative stress, interferon signaling, ferroptosis, neuronal remodeling, and amyloid processing. These transcriptional changes were accompanied by disrupted glutathione synthesis, altered ferritin-mediated iron storage and heme metabolism, and selective impairment of lipid raft antioxidant defenses, resulting in a 40% increase in lipid raft 4-hydroxynonenal (HNE) with WTC dust with DEP trending similarly, and at least a 65% reduction in phospholipid hydroperoxide detoxification capacity, and 36% increase in the aggregation-prone Aβ42 peptide for both pollution sources. Notably, both exposures produced acute white-matter abnormalities within the corpus callosum despite the absence of bulk brain iron accumulation, indicating that redistribution of bioactive iron rather than total iron burden may be sufficient to promote oxidative injury. In contrast, WS produced a distinct transcriptional profile, lacked coordinated ferroptotic priming, failed to induce lipid peroxidation or Aβ42 accumulation, and showed minimal effects on iron metabolism. Together, these findings identify metal-associated oxidative mechanisms as a convergent pathway linking chemically distinct forms of AirP to ferroptotic vulnerability, amyloidogenic processing, and AD-relevant pathology.

Indexed as

Air pollutionGPx4Lipid raftsMetal neurotoxicityWhite matter vulnerability

Identifiers

PMID42748655
PMCPMC13595015

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