ArticleJornal brasileiro de nefrologia
Predictors of chronic kidney disease in children who underwent surgical correction of congenital heart disease: a long-term follow-up cohort study.
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionChronic kidney disease (CKD) has emerged as a relevant late complication in patients who have undergone surgical correction of congenital heart disease (CHD). Albuminuria has been highlighted as an early marker of subclinical renal injury, which may precede a reduction in glomerular filtration rate (GFR).
objectiveTo assess late renal outcomes in patients who underwent surgical correction of CHD and to identify independent predictors for the development of CKD.
methodsA retrospective cohort study including patients who underwent pediatric cardiac surgery with long-term outpatient follow-up. Renal function was assessed through estimated GFR and the presence of albuminuria. Clinical, surgical, and genetic variables were analyzed using a multivariate logistic regression model.
resultsCKD was observed in 20.6% of patients, while albuminuria was present in 16.4%. In the multivariate analysis, the presence of a genetic syndrome was identified as an independent predictor of CKD (OR 4.06; 95% CI 1.29-12.74). A RACHS-1 surgical score of 2 had a protective effect on renal outcomes.
conclusionsGenetic syndromes represent a significant risk factor for the progression of renal injury, while surgeries of lower complexity are associated with a better prognosis. These findings reinforce the importance of early screening for albuminuria and long-term nephrological follow-up in this population.
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