Evidence map›Paper›PMID 42748228›Full record

ArticleScience advances2026

Metabolic sensor AMPK licenses intestinal CD103

Thiago A Patente, Julian van Duijvenvoorde, Graham A Heieis, Eline C Brombacher, Leonard R Pelgrom, Joost Lambooij, Anna Zawistowska-Deniziak, Martina Erbì, Frank Otto, Arifa Ozir-Fazalalikhan and 9 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Thiago A PatenteLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-9333-869X
Julian van DuijvenvoordeLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0009-0003-1811-2465
Graham A HeieisLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-9864-7272
Eline C BrombacherLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-4475-5854
Leonard R PelgromLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-8422-6810
Joost LambooijLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-4853-5843
Anna Zawistowska-DeniziakLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-6990-9165
Martina ErbìLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0009-0002-2085-7872
Frank OttoLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Arifa Ozir-FazalalikhanLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-0613-8372
Sara BarnhoornLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
José J FernándezLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-7552-0076
Johan van der ReijdenDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands.
Alwin J van der HamLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-4532-9120
Lukas J A C HawinkelsDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-2274-9325
Bruno A GuigasLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-8856-5799
José A M BarbutoLaboratory of Tumor Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-9526-6781
Rick M MaizelsSchool of Infection and Immunity, University of Glasgow, 120 University Place, G12 8TA Glasgow, UK.
Bart EvertsLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-3764-5131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal dendritic cells (DCs) play a central role in maintaining gut tolerance through priming of peripheral regulatory T cells (pT

Indexed as

AMP-Activated Protein KinasesAntigens, CDDendritic CellsIntegrin alpha ChainsIntestinesT-Lymphocytes, RegulatoryAnimalsHumansImmune ToleranceIntestinal MucosaMetabolic ReprogrammingMiceRetinal DehydrogenaseTretinoinalpha E integrinsAMP-Activated Protein KinasesAntigens, CDIntegrin alpha ChainsRetinal DehydrogenaseTretinoin

Identifiers

PMID42748228
PMCPMC13580595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.