Evidence map›Paper›PMID 42748179›Full record

Trial reportPloS one2026

Assessing the effect of Loving-Kindness Meditation on pain and social well-being using a randomized controlled trial design.

Olivia Young, Katherine O'Connell, Naomi Nero, Melinda C Somers, Paige A Freeburg, Mary Ann Dutton, Abigail A Marsh

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04632875 (Identifying Neural Correlates of Altruism), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04632875 nacompletednot on this map

Identifying Neural Correlates of Altruism

TypeinterventionalSponsorGeorgetown UniversityRan2020 to 2021Enrolled75ConditionsMeditationArmsLoving-Kindness Meditation, Relaxation Meditation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olivia YoungDepartment of Psychology, Georgetown University, Washington, District of Columbia, United States of America.
Katherine O'ConnellInterdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, United States of America.ORCID https://orcid.org/0000-0002-9649-9007
Naomi NeroDepartment of Psychology, Georgetown University, Washington, District of Columbia, United States of America.ORCID https://orcid.org/0009-0004-7941-1482
Melinda C SomersDepartment of Psychology, Georgetown University, Washington, District of Columbia, United States of America.
Paige A FreeburgDepartment of Psychology, Yale University, New Haven, Connecticut, United States of America.ORCID https://orcid.org/0000-0001-6229-8314
Mary Ann DuttonDepartment of Psychiatry, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Abigail A MarshDepartment of Psychology, Georgetown University, Washington, District of Columbia, United States of America.

Funding

Translational Biomedical Science Training GrantTL1TR001431 · NCATS · GEORGETOWN UNIVERSITY · PI LEE, DEXTER L, SANDBERG, KATHRYN L · 2015 to 2024
$4.8M
Evaluating the impact of a social meditation training on acute pain experienceF31AT010423 · NCCIH · GEORGETOWN UNIVERSITY · PI O'CONNELL, KATHERINE · 2020 to 2021
$66k
NCATS NIH HHS TL1 TR001431NCCIH NIH HHS F31 AT010423
6 · The paper itself

Abstract

Loving-Kindness Meditation (LKM), a contemplative practice that aims to promote social well-being, has also been linked to lower self-reported pain symptoms. However, it remains unknown whether LKM can reduce pain through having a positive impact on social well-being, as well as whether LKM can improve self-reported acute pain and objectively measured acute pain tolerance among a general, healthy population. In this study (ClinicalTrials.gov; NCT04632875), participants (n = 69) completed either a 4-week online LKM training or an active control meditation training (Progressive Muscle Relaxation; PMR), followed by a novel, remote pain induction task: the wall sit test administered over video conference. This study used a two-arm, parallel-group randomized controlled trial design with stratified block randomization and a double-blind baseline session. We hypothesized that, relative to the PMR active control, LKM would improve social well-being, reduce subjective pain reports, and improve acute pain tolerance. Contrary to our hypotheses, the PMR active control training increased perceived social support relative to LKM (p = .028), and neither meditation decreased subjective pain or increased acute pain tolerance over time. Our data were collected during the unique circumstance of the early COVID-19 pandemic, and it is important to interpret our results with consideration of widespread restrictions on in-person social contact and elevated stress during this period. This context may have constrained participants' opportunities for social connection and influenced reports of social support and pain. Nevertheless, our findings add to the current understanding of how meditation, social wellness, and pain may be related.

Indexed as

MeditationPainPain ManagementAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedSocial Support

Identifiers

PMID42748179
PMCPMC13580951

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.