ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026
Paediatric perioperative hypersensitivity reactions: Analysis of the French GERAP network database.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Paediatric perioperative hypersensitivity reactions: Analysis of the French GERAP network database.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerioperative hypersensitivity (POH) reactions are rare but potentially life-threatening and remain poorly characterised in children. We analysed the largest available French paediatric cohort to describe the epidemiology, causal agents, temporal trends and phenotypes.
methodsWe pooled data from paediatric patients (<18 years) included in six previously published GERAP surveys (1997-2012) and the GERAP computerised database (2017-2024), all evaluated in centres of the GERAP network according to current guidelines. The primary objective was to compare POH phenotypes with and without causal agent identification.
resultsOf 4605 POH reactions recorded, 461 (10%) occurred in children (median age 14 [10-16] years; 47% female). Reactions were grade 1 in 50%, grade 2 in 23%, grade 3 in 26% and grade 4 in 1%. The causal agent was identified in 199 (43%) cases, mainly neuromuscular blocking agents (NMBAs) (31%), latex (30%) and antibiotics (16%). Identification was more frequent in anaphylaxis than in isolated cutaneous reactions (61% vs. 25%, p < .001). Latex-related reactions disappeared after 2017. Patients in whom a causal agent was identified had more severe reactions (grade 3-4: 46% vs. 13%; p < .001), more cardiovascular and respiratory involvement, and higher acute serum tryptase (median 16.0 vs. 4.0 μg/L; p < .001) than those without identification.
conclusionsPaediatric POH are not uncommon and may be life-threatening. All suspected reactions, including isolated cutaneous signs, warrant referral to specialised allergy centres given the still low identification rate and the continuing burden of NMBA- and antibiotic-related reactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.