ArticleEmerging infectious diseases2026
Correlations between Wastewater Concentrations of Influenza A and Respiratory Syncytial Viruses and Clinical Laboratory Testing and Hospitalization Data, California, USA.
Article in Emerging infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We evaluated correlations between influenza A virus and respiratory syncytial virus (RSV) wastewater concentrations in California, USA, and 3 clinical laboratory-based disease surveillance datasets: sentinel laboratory surveillance, mandatory electronic laboratory reporting data, and laboratory-confirmed influenza hospitalizations. We evaluated data from 10 counties and 18 wastewater treatment plants in California during July 2022-March 2024. We observed strong, positive, and statistically significant correlations between individual sewershed-level wastewater concentrations and county-aggregated wastewater concentrations of influenza A and RSV and clinical laboratory-based surveillance datasets (median Kendall τ 0.62 [range 0.40-0.78]; p<0.05). A lead-lag analysis did not show consistent evidence of wastewater leading other surveillance datasets across all counties and wastewater treatment plants (influenza A -16 to 22 days; RSV -8 to 35 days). Wastewater surveillance can augment other disease surveillance modalities and improve situational awareness of influenza A and RSV transmission in communities.
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