Evidence map›Paper›PMID 42747773›Full record

ArticleGeneral thoracic and cardiovascular surgery2026

Sealing strength and application efficiency of the microbubble fibrin sealant technique: influence of PGA sheet type in an ex vivo porcine lung model.

Ryuji Nakamura, Katsuhiro Okuda, Shin Hosokawa, Eiji Nakatani, Takayuki Murase, Singo Inaguma, Kensuke Iguchi, Kensuke Chiba, Tsutomu Tatematsu, Keisuke Yokota

Abstract read
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In one paragraph

Article in General thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ryuji NakamuraDepartment of Thoracic and Pediatric Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.ORCID http://orcid.org/0009-0009-1927-3969
Katsuhiro OkudaDepartment of Thoracic and Pediatric Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan. kokuda@med.nagoya-cu.ac.jp.ORCID http://orcid.org/0000-0003-0099-2348
Shin HosokawaDepartment of Thoracic and Pediatric Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.
Eiji NakataniDepartment of Biostatistics and Health Data Science, Graduate School of Medical Science and Medical School, Nagoya City University, Nagoya, Japan.
Takayuki MuraseDepartment of Pathology and Molecular Diagnostics, Graduate School of Medical Sciences and Medical School, Nagoya City University, Nagoya, Japan.
Singo InagumaDepartment of Pathology and Molecular Diagnostics, Graduate School of Medical Sciences and Medical School, Nagoya City University, Nagoya, Japan.
Kensuke IguchiDepartment of Thoracic and Pediatric Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.
Kensuke ChibaDepartment of Thoracic and Pediatric Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.
Tsutomu TatematsuDepartment of Thoracic and Pediatric Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.
Keisuke YokotaDepartment of Thoracic and Pediatric Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.

Funding

Japan Society for the Promotion of Science JP24K15749
6 · The paper itself

Abstract

objectiveWe previously proposed the microbubble fibrin sealant application technique (microbubble technique) for the precise and efficient delivery of fibrinogen to air leak sites. However, its sealing strength and application efficiency are still unclear. This study aimed to assess the non-inferiority of the microbubble technique in sealing strength, the influence of polyglycolic acid (PGA) sheet type, and its effect on reducing fibrin sealant runoff.

methodsPleural defects were created in ex vivo porcine lungs. Fibrin sealant was applied using either the conventional or microbubble technique with two types of PGA sheets. Seal-breaking pressure was measured, and the non-inferiority of the microbubble technique was assessed. The interaction between the application technique and the PGA sheet type was analyzed. In addition, the fibrin sealant runoff was evaluated on an inclined lung surface.

resultsUsing the Neoveil® PGA sheet, the microbubble technique demonstrated seal-breaking pressure not inferior to that of the conventional technique (40.2 ± 8.4 vs. 40.9 ± 6.0 cmH

conclusionThe microbubble technique demonstrated sealing strength comparable to that of the conventional technique while reducing fibrin sealant runoff. However, sealing performance appeared to depend on the PGA sheet type.

Indexed as

Fibrin sealantPolyglycolic acid sheetPostoperative air leak

Identifiers

PMID42747773

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.