ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Validation of an innovative tissue-cage/beads rabbit model for ex vivo determination of minimum levels of Staphylococcus aureus biofilm eradication.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To offset limitations of current methods of antibiofilm activity determination, including in vitro technical variations and the limited number of conditions assessable in animals, we describe a rabbit tissue-cage model allowing ex vivo screening of antimicrobials against in vivo-formed S. aureus biofilm. Cages containing six beads of polyethylene, titanium or steel served as support for S. aureus SH1000 biofilm formation. In vitro validation steps included: (i) quantification of bead-adherent bacteria after 24 h incubation in bacterial suspension, measured at 4.7 (95%CI, 4.5-4.9) log10 CFU/bead, with no difference between biomaterials, allowing the selection of polyethylene for animal experiments due to its lighter weight; and (ii) minimum concentration eradicating 90% of biofilm-embedded bacteria (MBEC
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