Evidence map›Paper›PMID 42747701›Full record

ArticleEJNMMI radiopharmacy and chemistry2026

Optimization, automation and validation of NOP receptor PET radiopharmaceutical, [

Daniel L Yokell, Maeva Dhaynaut, Ramesh Neelamegam, Peter A Rice, Jacqueline Noel, Marc D Normandin, Diego A Pizzagalli, Georges El Fakhri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel L Yokell *Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Edwards 019, Boston, MA, 02114, USA.
Maeva Dhaynaut *Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Edwards 019, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0002-8529-5746
Ramesh NeelamegamGordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Edwards 019, Boston, MA, 02114, USA.
Peter A RiceGordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Edwards 019, Boston, MA, 02114, USA.
Jacqueline NoelGordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Edwards 019, Boston, MA, 02114, USA.
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Edwards 019, Boston, MA, 02114, USA.
Diego A PizzagalliCenter for Depression, Anxiety and Stress Research & McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Edwards 019, Boston, MA, 02114, USA. georges.elfakhri@yale.edu.

Funding

Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI FRANK, MICHAEL J. · 2020 to 2024
$15.9M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
National Institute of Mental Health and Neurosciences P50 MH119467National Institute of Mental Health and Neurosciences R37 MH068376NIMH NIH HHS P50 MH119467NIMH NIH HHS R37 MH068376
6 · The paper itself

Abstract

backgroundIn vivo human studies of the nociceptin/orphanin FQ peptide (NOP) receptor have been limited by the availability and reliable production of suitable PET radioligands. [

resultsWe developed a fully automated loop radiomethylation method for the production of [

conclusionsA robust, fully automated, and cGMP-compliant production method for [

Indexed as

[11C]NOP-1ACarbon-11cGMP [11C]-radiochemistryNOP PET imagingTracerlab FXC pro

Identifiers

PMID42747701
PMCPMC13582667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.