Evidence map›Paper›PMID 42747582›Full record

ReviewMolecular biology reports2026

Collateral sensitivity-harnessing microbial vulnerabilities as a solution to antimicrobial resistance.

Rishav Jana, Priyanka Bhowmik

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rishav JanaDepartment of Biological Sciences, School of Life Science & Biotechnology, Adamas University, Barasat - Barrackpore Road, P.O. - Jagannathpur, District - 24 Parganas (North), Kolkata - 700 126, Adamas Knowledge City, West Bengal, India.
Priyanka BhowmikDepartment of Biological Sciences, School of Life Science & Biotechnology, Adamas University, Barasat - Barrackpore Road, P.O. - Jagannathpur, District - 24 Parganas (North), Kolkata - 700 126, Adamas Knowledge City, West Bengal, India. priyanka1.bhowmik@adamasuniversity.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria exhibit an evolutionary trade-off through their development of collateral sensitivity (CS) which allows them to resist one antibiotic while becoming more vulnerable to another. This vulnerability offers a compelling therapeutic opportunity by selecting against resistant isolates. Laboratory evolution studies, genome sequencing, deep mutagenesis and use of artificial intelligence and machine learning can design the bespoke strategy against multi-drug-resistant bacteria. This review discusses about recent studies that are rationally designed to harness this evolutionary trade-off for the development of alternative antimicrobial strategies. The translational barriers to the clinical implementation of CS are addressed and evidence-based design principles for optimization of CS-guided therapy are discussed.

Indexed as

Anti-Bacterial AgentsBacteriaDrug Collateral SensitivityDrug Resistance, BacterialDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntibiotic resistanceAntimicrobial therapyBacterial evolutionCollateral sensitivityEvolutionary trade-off

Identifiers

PMID42747582

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.