Evidence map›Paper›PMID 42747544›Full record

ReviewLung2026

Inhalable Dry Powders of Antimicrobial Agents in Respiratory Diseases.

Hasham Shafi, David Encinas-Basurto, Y Peter Di, Heidi M Mansour

Abstract readReview
In one paragraph

Review in Lung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hasham ShafiCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL, 34987, USA.
David Encinas-BasurtoDepartment of Chemical Engineering and Metallurgy, University of Sonora, 83000, Hermosillo, Sonora, Mexico.
Y Peter DiCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL, 34987, USA.
Heidi M MansourCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL, 34987, USA. hmansour@fiu.edu.

Funding

Developing a novel class of peptide antibiotics targeting carbapenem-resistant Gram-negative organismsR01AI176537 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanpu Peter Di · 2023 to 2026
$3.5M
Optimization of a novel antimicrobial for pulmonary delivery to fight respiratory infectionsR21AI191628 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI Yuanpu Peter Di, Heidi M. Mansour · 2025 to 2026
$406k
National Institute of Allergy and Infectious Diseases R21AI191628NIAID NIH HHS R01 AI176537NIAID NIH HHS R21 AI191628
6 · The paper itself

Abstract

backgroundRespiratory infections remain a major global health burden despite advances in systemic antimicrobial therapy. Antimicrobial dry powder inhalers (DPIs) have emerged as precision-engineered pulmonary delivery platforms capable of achieving high local drug concentrations while minimizing systemic toxicity.

objectiveThis review examines the historical evolution, pharmacological landscape, particle engineering technologies, translational challenges, and clinical progress of antibacterial, antiviral, and antifungal DPIs. CONTENT: We trace the evolution of antimicrobial DPIs from early aerosolized therapies to contemporary engineered systems, integratingdisease targets, pharmacological agents, particle and formulation engineering, inhaler technologies, patents, clinical development andregulatory milestones. Particular emphasis is placed on formulations supported by in vivo efficacy, clinical investigation or regulatoryapproval, highlighting advances in tuberculosis, chronic bacterial infections, viral respiratory diseases and pulmonary fungal infections.

conclusionsAntimicrobial DPIs are evolving toward precision pulmonary therapies, highlighting their expanding role in chronic infections, pandemic preparedness, and next-generation pulmonary anti-infective therapy. Overcoming dose, deposition, stability, andtranslational barriers will be critical for broader clinical adoption.

Indexed as

Anti-Infective AgentsDry Powder InhalersRespiratory Tract InfectionsAdministration, InhalationAerosolsAnimalsHumansPowdersAerosolsAnti-Infective AgentsPowders

Identifiers

PMID42747544
PMCPMC13582049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.