Evidence map›Paper›PMID 42747507›Full record

SynthesisClinical oral investigations2026

Effects of periodontally accelerated osteogenic orthodontics on treatment duration and periodontal outcomes: a systematic review and meta-analysis.

Han Xu, Kaile Sheng, Yan Wang, Mengyao Ding, Kun Wang, Xiaohang Xu, Chris Tat Chuen Fok, Qinzi Xie, Yunnan Jin, Chuyi Jin and 4 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Han XuStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Kaile ShengStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Yan WangStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Mengyao DingStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Kun WangStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Xiaohang XuStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Chris Tat Chuen FokDivision of Periodontology & Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, SAR, China.
Qinzi XieStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Yunnan JinStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Chuyi JinStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Yifan XieStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Lipei LiuStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China.
Xing ChenStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China. 316679138@qq.com.
Cheng DingStomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, Zhejiang Province, China. cheng0710@gmail.com.

Funding

the Hangzhou Biological Medicine and Health Industry Development Support Science and Technology Project No. 2023WJC034
6 · The paper itself

Abstract

objectivesThis review examined whether periodontally accelerated osteogenic orthodontics (PAOO) reduces orthodontic treatment time and whether it alters periodontal outcomes, including alveolar bone thickness, root length, and soft-tissue measures. MATERIALS AND

methodsPubMed, Embase, Web of Science, Google Scholar, the Cochrane Library, and ClinicalTrials.gov were searched through June 3, 2026. Studies comparing PAOO with conventional unassisted orthodontic treatments with relevant clinical or radiographic outcomes were included. Two reviewers independently extracted data and assessed risk of bias using ROBINS-I, while the certainty of evidence was rated with GRADE. Comparable continuous outcomes were pooled as mean differences.

resultsEleven non-randomized studies were included. PAOO was associated with a shorter treatment duration (MD = -7.51 months, 95% CI = -10.42 to -4.59, p < 0.001), albeit with high heterogeneity (I

conclusionsPAOO may shorten treatment and increase buccal bone thickness, but evidence of lingual bone gain was restricted to selected measurement sites. Keratinized gingival width and root length did not differ significantly between groups. Because all included studies were non-randomized and the certainty of evidence ranged from very low to low, these findings should be interpreted cautiously. Well-designed randomized trials with longer follow-up are needed. CLINICAL RELEVANCE: PAOO may represent a potential treatment option for selected adult patients, particularly those undergoing anterior decompensation or camouflage treatment with thin buccal bone, but the evidence remains limited.

Indexed as

OsteogenesisHumansTreatment OutcomeAlveolar boneMeta-analysisOrthodonticsPeriodontally accelerated osteogenic orthodonticsPeriodontal tissues

Identifiers

PMID42747507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.