Evidence map›Paper›PMID 42747315›Full record

ArticleGut microbes2026

Gut microbiota functional remodeling and butyrate depletion amplify anti-Ro/La antibody-driven type I interferon activation in neonatal lupus.

Wenqiang Sun, Yihui Li, Xue Liu, Shuyang Yu, Wenmei Li, Huawei Wang, Haifeng Geng, Lili Li, Jinhui Hu, Jie Huo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wenqiang SunDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.ORCID 0000-0002-9281-1737
Yihui LiDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Xue LiuDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Shuyang YuSuzhou Medical College, Soochow University, Suzhou, China.
Wenmei LiDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Huawei WangDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Haifeng GengDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Lili LiDepartment of Neonatology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Jinhui HuNeonatal Medical Center, Huai'an Maternal and Child Health Care Center, Huai'an, China.
Jie HuoDepartment of Neonatology, Yangzhou Maternity and Child Health Care Hospital, Yangzhou, China.
Wanyan ZhangDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jing FuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xinyun JinDepartment of Pediatric Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.
Heng LiDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Xihui ZhouDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xueping ZhuDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.ORCID 0000-0002-3502-7655

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early-life gut microbiome may influence susceptibility to antibody-mediated neonatal autoimmunity, but the underlying mechanisms remain poorly understood. We investigated whether gut microbial functional capacity and metabolites influence autoantibody-dependent immune activation in 90 neonates, including healthy controls, anti-Ro/La-exposed neonates without neonatal lupus erythematosus (No-NLE), and neonates with NLE (

Indexed as

AutoantibodiesButyratesGastrointestinal MicrobiomeInterferon Type ILupus Erythematosus, SystemicBacteriaFemaleHumansInfant, NewbornMaleAutoantibodiesButyratesInterferon Type IButyrategut microbial metabolismneonatal lupus erythematosusshotgun metagenomicstype I interferon

Identifiers

PMID42747315
PMCPMC13596901

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.