Evidence map›Paper›PMID 42747203›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Collagen-Binding IL-15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self-Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity.

Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yaqi Yang *Key Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Xiaoxiao Liu *Key Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Junqiang Ding *Key Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Jinliang XuDepartment of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jianhua ZhangKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Hanchang ZhangKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Rong YangKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-7753-695X
Sha LiKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Lu ZhengKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Runping SuKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Yue ZhaoKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Jianxiao WuKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Hao LiOrgan Transplantation Clinical Medical Center of Xiamen University, Department of General Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-1624-8970
Changyou ZhanDepartment of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-5215-2829
Xihui GaoKey Laboratory of Medical Molecular Virology of MOE/NHC/CAMS, School of Basic Medical Sciences, Department of Pharmacy, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Pudong Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2149-0008

Funding

China Postdoctoral Science Foundation 2024M760539China Postdoctoral Science Foundation 2025M773560National Natural Science Foundation of China 82572390Postdoctoral Fellowship Program of China Postdoctoral Science Foundation GZC20250997Postdoctoral Fellowship Program of China Postdoctoral Science Foundation GZC20252365Shanghai Municipal Science and Technology Major Project ZD2021CY001
6 · The paper itself

Abstract

The immunosuppressive microenvironment limits immunotherapy in triple-negative breast cancer (TNBC). Interleukin-15 (IL-15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL15C-CBD, an immunocytokine comprising an IL-15/IL-15Rα sushi-domain complex fused to a collagen-binding domain, thereby establishing a self-reinforcing immunostimulatory milieu within tumors. Intratumoral administered OV-IL15C-CBD lyses tumor cells and secretes IL15C-CBD that anchors to extracellular matrix collagens, forming a localized cytokine reservoir. In the murine 4T1 TNBC model, this strategy profoundly remodeled the microenvironment by recruiting CD8

Indexed as

collagen‐binding domainimmunosuppressive tumor microenvironmentinterleukin ‐ 15oncolytic adenovirustriple‐negative breast cancertumor immunotherapy

Identifiers

PMID42747203
PMCPMC13580172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.