Evidence map›Paper›PMID 42747196›Full record

ArticleApplied and environmental microbiology2026

Genomic prospecting and biochemical characterization of a novel thermostable 3-quinuclidinone reductase from hot spring metagenomes for efficient biocatalysis.

Deshuai Lou, Jinghao Cui, Jingfa Duan, Bingpu Zhou, Yue Wang, Dong Wang, Jun Tan, Hongtao Duan

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deshuai LouChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, China.
Jinghao CuiChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, China.
Jingfa DuanChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, China.
Bingpu ZhouChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, China.
Yue WangChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, China.
Dong WangSchool of Information Science and Engineering, University of Jinan, Jinan, China.ORCID 0000-0002-5249-5434
Jun TanChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, China.
Hongtao DuanSchool of Medicine, South China University of Technology, Guangzhou, China.ORCID 0009-0008-6743-941X

Funding

Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0947
6 · The paper itself

Abstract

This study presents the discovery and characterization of a novel thermophilic 3-quinuclidinone reductase (ScQR) identified through metagenomic mining of hot spring environments. ScQR, a member of the short-chain dehydrogenase/reductase (SDR) superfamily, was heterologously expressed in

Indexed as

Hot SpringsMetagenomeOxidoreductasesQuinuclidinesBiocatalysisEnzyme StabilityEscherichia coliHot TemperatureHydrogen-Ion ConcentrationMolecular Dynamics SimulationSubstrate SpecificityOxidoreductasesQuinuclidinescomputational designhot spring microorganismsmetagenomics

Identifiers

PMID42747196
PMCPMC13689474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.