ReviewGut microbes2026
The gut microbiota as a regulator of intestinal stem-cell fate: bacterial and fungal control of differentiation and regeneration.
Review in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal stem cells (ISCs) sustain epithelial homeostasis and regeneration in a niche that is shaped by epithelial, stromal, immune, and microbial inputs. This review examines how bacterial and fungal signals influence ISC activity and epithelial repair through microbial metabolites, immune relays, and epithelial sensing. Bacterial metabolites and structural ligands act through Wnt/β-catenin, AHR, IL-22-STAT3, Hippo-YAP, and related pathways, and the effects vary according to the ligand involved, responding cell type, and tissue state. Evidence for fungi is more limited: some fungal products engage repair-associated pathways, whereas improved barrier function or reduced inflammation have been observed without directly measuring ISC fate. Therefore, we distinguish direct changes in stem-cell self-renewal, lineage allocation, or regenerative state from indirect evidence based on epithelial repair. This evidence-based framework evaluates how multi-kingdom microbial signals may shape intestinal renewal and identifies key mechanistic gaps.
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