Evidence map›Paper›PMID 42746636›Full record

ArticleChem2026

Geometric Divergence in Nanostructural Fates of Coassembled Peptides Leads to Broadening of Morphology-Based Optoelectronic Property Outcomes.

Yuyao Kuang, Ze-Fan Yao, Sydney To, Sheng Wei Tang, Joni Spencer, Ronald Dat Phung, Hao-Tian Wu, Catherine Salgado, Li Xing, Karolina Sulowska and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuyao KuangDepartment of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.
Ze-Fan YaoDepartment of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.
Sydney ToDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.
Sheng Wei TangDepartment of Chemistry, School of Physical Sciences, University of California, Irvine, CA 92697, USA.
Joni SpencerDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.
Ronald Dat PhungDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.
Hao-Tian WuBeijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Center of Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 China.
Catherine SalgadoDepartment of Biomedical Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.
Li XingIrvine Materials Research Institute, University of California, Irvine, CA 92697, USA.
Karolina SulowskaInstitute of Advanced Materials, Wroclaw University of Science and Technology, Wybrzeże Stanisława Wyspiańskiego 27, Wrocław 50-344, Poland.
Joanna Olesiak-BańskaInstitute of Advanced Materials, Wroclaw University of Science and Technology, Wybrzeże Stanisława Wyspiańskiego 27, Wrocław 50-344, Poland.
Jian PeiBeijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Center of Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 China.
Elizabeth M Y LeeDepartment of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.
Herdeline Ann M ArdoñaDepartment of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA.

Funding

Optically Promoting Cardiac Maturation Using Engineered PeptidesR01HL164348 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Herdeline Ann Mallari Ardona · 2023 to 2026
$2.3M
NHLBI NIH HHS R01 HL164348
6 · The paper itself

Abstract

Sequence-defined hierarchical structure critically governs the function and emergent properties of biomacromolecules. However, introducing functional yet bulky π-conjugated synthetic units imposes geometric constraints that complicate the rational prediction of structuremorphology correlations for engineered biomacromolecules. Here, we report an intriguing coassembly behavior of a sequence-matched peptide pair bearing energy-transporting π-electron donor/acceptor cores (DDD-4T/DDD-PDI). Individually, DDD-4T forms twisted 1-D chiral nanofibers, whereas DDD-PDI assembles into achiral 2-D bundle-like nanostructures. Upon coassembly, heterotypic interactions between a more torsionally compliant donor core and comparatively rigid acceptor core produce hybrid chiral nanostructures distinct from either pristine state. These variations in nanostructure dimensionality and local chirality result in differential photophysical and optoelectronic properties. Thermal annealing and kinetic control of acidification further direct assemblies into alternative local minima, underscoring pathway-dependent supramolecular interactions. Collectively, we present a design principle for bioelectronic materials whereby broadening property-defining morphological fates could be driven by torsional mismatch between supramolecular units.

Indexed as

bioelectronicsdonor-acceptorNanostructurespeptidesself-assemblysupramolecular chemistry

Identifiers

PMID42746636
PMCPMC13577602

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.