Evidence map›Paper›PMID 42746633›Full record

ArticleCell press blue2026

Pre-vaccine sentinel antibodies predict blunted vaccine responses.

Lusheng Song, Jin G Park, Ji Qiu, Vel Murugan, Seyedmasoud Mousavi, Ching-Wen Hou, D Mitchell Magee, Zhongxue Chen, Yunro Chung, Stacy Williams and 48 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell press blue, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors.

Lusheng SongVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Jin G ParkVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Ji QiuVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Vel MuruganVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Seyedmasoud MousaviSchool of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.
Ching-Wen HouVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
D Mitchell MageeVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Zhongxue ChenCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Yunro ChungVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Stacy WilliamsVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Deborah AdamVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Bihong GuoVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Candyce McDanielVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Toria TrendlerVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Gabe RiceVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Kelly ConnardVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Bradley BobbettVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Michael RitchieVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Izamar GarciaVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Guillermo Sebastian Trivino SotoVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Giovanna CaruthVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Eleni KatergarisVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Kristen SeifertVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Veronica BoyleVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Heewook LeeSchool of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.
Damodara Rao MenduDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Viviana SimonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Komal SrivastavaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Mike RyanInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Elena KowalskyInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Patrick BreadsVaccine, Immunity and Cancer Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
David FettererVaccine, Immunity and Cancer Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Troy KempVaccine, Immunity and Cancer Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Ann KhalsaValleywise Health, Phoenix, AZ, USA.
Lora NordstromValleywise Health, Phoenix, AZ, USA.
Michael D WhiteValleywise Health, Phoenix, AZ, USA.
Raquel SalgadoValleywise Health, Phoenix, AZ, USA.
Chad M VanDenBergClinical Research Services, Midwestern University, Glendale, AZ, USA.
Natacha MontalvoClinical Research Services, Midwestern University, Glendale, AZ, USA.
Craig WoodsClinical Research Services, Midwestern University, Glendale, AZ, USA.
Rajat WaliaNorton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA.
David CarpentieriPhoenix Children's Hospital, Phoenix, AZ, USA.
Peter ArdenDept. Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Christine L KurylaDept. Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Anay PatelDept. Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Lauren StieneDept. Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Imke FolkertsDept. Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Stefani N ThomasDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Anne DavidsonInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Thomas HickeyGeneral Dynamics Information Technology, Office of Regulated Activities, Fort Detrick, MD, USA.
Nancy RocheVaccine, Immunity and Cancer Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Ligia PintoVaccine, Immunity and Cancer Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Norman KleimanDept. Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Carlos Cordon-CardoDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Amy B KargerDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Peter GregersenInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Joshua LaBaerVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI Irene M. Ghobrial · 1985 to 2026
$330.6M
Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI JEREMY M. BOSS · 2014 to 2026
$76.6M
Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neckR33CA281802 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LABAER, JOSHUA · 2023 to 2025
$1.1M
Multiplexed In Solution Protein Array (MISPA) for identifying novel protein interactions in cancer and for early detection of immune responses in pathogen-induced cancersR21CA196442 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LABAER, JOSHUA · 2015 to 2017
$672k
NCI NIH HHS P30 CA006516NCI NIH HHS R21 CA196442NCI NIH HHS R33 CA281802NIAID NIH HHS U19 AI110483NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Predicting which individuals will mount poor antibody responses before vaccination could improve personalized vaccination strategies. Here, we conducted a national longitudinal study of humoral immune responses to 185 antigens, including SARS-CoV-2 (n = 3), common microbial pathogens (n = 157), and autoantigens (n = 25), in 1,644 immunosuppressed patients and 2,445 healthy individuals before and after COVID-19 vaccination. Although blunted COVID-19 vaccine responses were more frequent in solid organ transplant recipients and individuals with multiple myeloma, autoimmune disease, inflammatory bowel disease, and human immunodeficiency virus, responses were highly heterogeneous within every cohort, and approximately 5-6% of healthy individuals also mounted weak responses. Pre-existing antibodies to common microbes, including

Indexed as

COVID-19deep-learning-based modelimmunosuppressionpre-existing antimicrobialsentinel antibodyVaccine response

Identifiers

PMID42746633
PMCPMC13577455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.