ArticleTzu chi medical journal
Chloride-dependent mechanisms contribute to urinary bladder smooth muscle contractility: Pharmacological and molecular evidence from rat bladder tissue.
Article in Tzu chi medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To investigate the functional role of chloride-dependent signaling pathways in urinary bladder smooth muscle (SM) contractility and to evaluate the expression of ClC-3 and CLCA4 in rat bladder tissue. Materials and Methods: Expression of ClC-3 and CLCA4 in rat bladder tissue was examined using Western blotting and immunohistochemistry. Functional studies were conducted using isolated bladder SM strips (2 mm × 2 mm × 10 mm) from adult male Wistar rats mounted in organ bath chambers for isometric tension recording. Potassium chloride (KCl)-induced contractions were assessed under varying extracellular chloride concentrations (138-8 mM) and after substitution with Br Results: ClC-3 and CLCA4 were expressed in both urothelial and SM layers. Reduction of extracellular chloride concentration significantly attenuated KCl-induced contractions in a concentration-dependent manner ( Conclusion: The present study provides pharmacological and molecular evidence supporting a contributory role of chloride-dependent signaling in bladder SM contractility under
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