Evidence map›Paper›PMID 42746563›Full record

ArticleCell press blue2026

TLR7/9 and type I interferon signaling reprogram neutrophil NET responses and impair antibacterial defense in systemic lupus erythematosus.

Eden G TenBarge, Ashley D Wise, Morgan L Hetzel, Helene A Hoover, Helia Esfandiari, Bailey E Holder, Eva Belevska, Ellie C Mennen, Sarah R McDaniel, Nicole M Vaccaro and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell press blue, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Eden G TenBargeDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Ashley D WiseDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Morgan L HetzelDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Helene A HooverDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Helia EsfandiariDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Bailey E HolderDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Eva BelevskaDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Ellie C MennenDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Sarah R McDanielDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Nicole M VaccaroDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Courtney C LuccaDivision of Rheumatology, University of Tennessee Medical Center, Knoxville, TN, USA.
Jonathan M WilliamsDivision of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer FerrisDivision of Rheumatology, University of Tennessee Medical Center, Knoxville, TN, USA.
Timothy E SparerDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Leslie J CroffordDivision of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffry D BieberDivision of Rheumatology, University of Tennessee Medical Center, Knoxville, TN, USA.
Andrew J MonteithDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.

Funding

Defining the mitochondrial metabolic regulation of systemic innate inflammationR35GM154838 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Andrew J Monteith · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM154838
6 · The paper itself

Abstract

Patients with systemic lupus erythematosus (SLE) are susceptible to bacterial infections, but the mechanisms remain unclear. We found that

Identifiers

PMID42746563
PMCPMC13576733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.