ArticleAdvances in radiation oncology2026
Computer Tomography-Based Target Volume Delineation and Clinical Outcomes of Low-Dose Radiation Therapy for Knee Osteoarthritis.
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Purpose: Low-dose radiation therapy is a noninvasive and cost-effective treatment modality used to alleviate pain and improve joint function in patients with knee osteoarthritis. However, standardized guidelines for computed tomography (CT)-based target delineation remain limited. This study aims to evaluate the feasibility and safety of low-dose radiation therapy using a CT-based, anatomy-guided clinical target volume that incorporates both bony and soft tissue structures. Methods and Materials: We conducted a retrospective analysis of patients with knee osteoarthritis who received low-dose radiation therapy at our institution. The clinical target volume was delineated on simulation CT to encompass the entire knee joint. Patients received a total dose of 3 Gy, delivered in 6 fractions of 0.5 Gy each on nonconsecutive days. Pain was assessed using a 10-point visual analog scale (VAS) before treatment initiation and upon completion. Results: A total of 37 patients (median age 69 years; 17 men and 20 women) received treatment across 71 knee sites. The median follow-up was 4.2 months. The median pretreatment VAS score was 6 (range, 4-10), significantly decreasing to 2 (range, 0-5) posttreatment ( Conclusions: CT-based, anatomy-guided clinical target volume delineation for low-dose radiation therapy in knee osteoarthritis is feasible and safe, with significant pain reduction observed. This approach provides a reproducible framework that may better reflect patient-specific disease extent compared with conventional field-based techniques. Further prospective studies are warranted to validate its clinical impact.
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