Evidence map›Paper›PMID 42746516›Full record

ArticleCell biomaterials2026

Immune context governs stage-specific responses to depleting anti-PD-1 antibody in type 1 diabetes.

Yujia Zhai, Shuyun Dong, Lauren C Naatz, Tianxiao Zhang, Xiangyang Ye, Dean R Tantin, Tallulah Andrews, Mingnan Chen

Abstract read
In one paragraph

Article in Cell biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yujia ZhaiDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA.
Shuyun DongDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA.
Lauren C NaatzDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA.
Tianxiao ZhangDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA.
Xiangyang YeDepartment of Pharmacotherapy, University of Utah, Salt Lake City, UT, USA.
Dean R TantinDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Tallulah AndrewsDepartment of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.
Mingnan ChenDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA.

Funding

Targeted depletion of programmed death-1 positive cells, a method that not only stops autoimmune attack but also preserves adaptive immunityR01AI139535 · NIAID · UNIVERSITY OF UTAH · PI CHEN, MINGNAN · 2019 to 2024
$2.7M
PD-1 BiKE: Targeting and Depleting PD-1 Positive Cells for Autoimmune Disease TreatmentR21AI185716 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CHEN, MINGNAN · 2025 to 2025
$424k
A 3-In-One Design of CAR Tregs for Robust ImmunotoleranceR21AI188073 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CHEN, MINGNAN · 2025 to 2025
$424k
Albumin-Amended Antibody Drug Conjugate (A3DC) for ImmunosuppressionR03EB037114 · NIBIB · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CHEN, MINGNAN · 2025 to 2025
$77k
NIAID NIH HHS R01 AI139535NIAID NIH HHS R21 AI185716NIAID NIH HHS R21 AI188073NIBIB NIH HHS R03 EB037114
6 · The paper itself

Abstract

A depleting anti-PD-1 antibody (D-αPD-1) exhibits stage-dependent effects: delaying hyperglycemia onset in a murine early insulitis (E-insulitis) model but accelerating disease in late insulitis (L-insulitis). Compared with E-insulitis, L-insulitis pancreatic islets show elevated immune cell infiltration, a pronounced T

Identifiers

PMID42746516
PMCPMC13576528

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.