Evidence map›Paper›PMID 42746325›Full record

ArticleJournal of affective disorders reports2026

Predicting weekly instability in depressive symptoms among individuals diagnosed with Major Depressive Disorder using deep learning and passively-collected movement data.

Anna M Langener, George D Price, Dawson Haddox, Michael V Heinz, Daniel M Mackin, Matthew D Nemesure, Amanda C Collins, Damien Lekkas, Tess Z Griffin, Arvind Pillai and 3 more

Abstract read
In one paragraph

Article in Journal of affective disorders reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna M LangenerCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.ORCID 0000-0003-0058-0263
George D PriceCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Dawson HaddoxCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.ORCID 0009-0004-8595-6454
Michael V HeinzCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Daniel M MackinCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.ORCID 0000-0002-2188-2968
Matthew D NemesureDigital Data Design Institute, Harvard Business School, Harvard University, Cambridge, MA, United States.
Amanda C CollinsCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Damien LekkasCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Tess Z GriffinCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Arvind PillaiCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.ORCID 0000-0002-2489-1130
Subigya NepalDepartment of Computer Science, Dartmouth College, Lebanon, NH, United States.
Andrew T CampbellCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Nicholas C JacobsonCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.

Funding

Treatment Development & Evaluation CoreP30DA029926 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2011 to 2026
$21.5M
Personalized Deep Learning Models of Rapid Changes in Major Depressive Disorder Symptoms using Passive Sensor Data from Smartphones and Wearable DevicesR01MH123482 · NIMH · DARTMOUTH COLLEGE · PI JACOBSON, NICHOLAS CHARLES · 2020 to 2024
$2.6M
NIDA NIH HHS P30 DA029926NIMH NIH HHS R01 MH123482
6 · The paper itself

Abstract

Major Depressive Disorder (MDD) is a common mental health condition marked by persistent low mood, reduced motivation, and low energy. Persons with MDD often experience large fluctuations in their symptoms over hours and days, which can offer valuable clinical insights, highlighting potential targets for treatment and intervention. Yet, it remains unclear how accurately these acute symptom changes can be predicted. In this preregistered study, we examined whether deep learning models could predict short-term fluctuations in depressive symptoms among individuals diagnosed with MDD. Passively-collected accelerometry data, a ubiquitous, privacy-preserving data stream with empirical ties to MDD symptomatology, was used to predict instability in depressive symptoms. Our sample contains clinically-depressed individuals per a structured clinical interview (

Indexed as

Deep learningMajor depressive disorderPassive sensingStep CountZero Crossing Rate

Identifiers

PMID42746325
PMCPMC13577147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.