ArticleDementia & neuropsychologia2026
Neuropsychiatric symptoms and gait/balance are predictors of functional trajectories in dementias.
Article in Dementia & neuropsychologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dementias have heterogeneous functional decline trajectories, but little is known about the factors that shape this differential progression. Objective: To identify relevant predictors of functional decline in patients with dementia. Methods: A total of 76 subjects were included in this longitudinal retrospective, observational study. Functional outcome was assessed using the Technology-Activities of Daily Living Questionnaire (T-ADLQ), a 33-item scale encompassing basic, instrumental, and advanced activities of daily living (ADLs), with higher scores indicating greater deterioration. Participants were assessed three times: at baseline, and after a mean follow-up of 6.2 and 11.2 months, respectively. Cognitive and noncognitive variables were evaluated as predictors of functional decline using a linear mixed-effect model. Results: Females represented 63.2% of the sample. Subjects had a mean age of 79.5 (±7.9) years, 6.2 (±4.3) years of education, and a Global Deterioration Scale (GDS) score of 4.7 (±0.68) (median 5; range, 4-6). The linear mixed-effect model (R Conclusion: This study underscores the importance of noncognitive predictors of functional trajectories in established dementia. In particular, neuropsychiatric symptoms and gait should be considered during the follow-up of people living with dementia to ensure tailored interventions and counseling for patients and their families. These findings support the inclusion of gait variables in further longitudinal studies on dementia prognosis.
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