ArticleAdvances in radiation oncology2026
Low-Dose Radiation Therapy (LDRT) for Osteoarthritis: A Retrospective Study of 94 Patients and 136 Joints Treated.
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This retrospective study aims to examine the efficacy of low-dose radiation therapy (LDRT) delivered via a linear accelerator in patients with osteoarthritis, measuring pain relief across various joints. Methods and Materials: A total of 94 patients and a total of 136 affected joints were treated with LDRT between January 2023 and May 2025 at a radiation therapy institute. Each patient received 6 treatments of 0.5 Gy every other day, totaling 3 Gy over the course of 2 weeks. Pain was documented using the numeric rating scale (NRS) before treatment (preradiation therapy) and at follow-up visits approximately 12 weeks posttreatment, with the von Pannewitz score also assessed at follow-up. Results: The mean age of patients was 74.5 years, with 38% male and 62% female patients. The treated joints included 61 hands (45%), 46 knees (34%), 15 shoulders (11%), 8 hips (6%), and 6 feet (4%). The mean pain score before treatment was 7.30 ± 1.90, while after treatment it dropped to 2.58 ± 3.09 on the NRS scale ( Conclusions: The study indicates that LDRT may be a safe, noninvasive option for treating osteoarthritis-related pain and improving joint function. Well-powered randomized controlled trials, especially with an American cohort, are required in the future to confirm these findings.
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